62479

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2464931..2465730 Replicon chromosome
Accession NZ_CP015138
Organism Escherichia coli strain Ecol_732

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag A4X18_RS12115 Protein ID WP_000347251.1
Coordinates 2464931..2465395 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag A4X18_RS12120 Protein ID WP_001296435.1
Coordinates 2465395..2465730 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4X18_RS12085 2459932..2460366 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
A4X18_RS12090 2460384..2461262 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
A4X18_RS12095 2461252..2462031 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
A4X18_RS12100 2462042..2462515 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
A4X18_RS12105 2462538..2463818 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
A4X18_RS12110 2464067..2464876 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
A4X18_RS12115 2464931..2465395 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
A4X18_RS12120 2465395..2465730 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
A4X18_RS12125 2465879..2467450 - 1572 WP_001273763.1 galactarate dehydratase -
A4X18_RS12130 2467825..2469159 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
A4X18_RS12135 2469175..2469945 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T62479 WP_000347251.1 NZ_CP015138:c2465395-2464931 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T62479 NZ_CP015138:c2465395-2464931 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT62479 WP_001296435.1 NZ_CP015138:c2465730-2465395 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT62479 NZ_CP015138:c2465730-2465395 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829CJ20


Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References