Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2098616..2099259 Replicon chromosome
Accession NZ_CP015099
Organism Glaesserella parasuis strain SC1401

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A4U84_RS10010 Protein ID WP_062924413.1
Coordinates 2098616..2098960 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A4U84_RS10015 Protein ID WP_012621770.1
Coordinates 2098963..2099259 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U84_RS09995 2094442..2095038 + 597 WP_021110885.1 DedA family protein -
A4U84_RS10000 2095221..2096312 - 1092 WP_062924411.1 murein transglycosylase A -
A4U84_RS10005 2096422..2098401 - 1980 WP_062924412.1 exoribonuclease II -
A4U84_RS10010 2098616..2098960 + 345 WP_062924413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4U84_RS10015 2098963..2099259 + 297 WP_012621770.1 helix-turn-helix domain-containing protein Antitoxin
A4U84_RS10020 2099385..2100449 - 1065 WP_071610276.1 DUF3944 domain-containing protein -
A4U84_RS10025 2100596..2101018 + 423 WP_043894462.1 helix-turn-helix transcriptional regulator -
A4U84_RS10030 2101135..2101923 - 789 WP_005714049.1 SDR family oxidoreductase -
A4U84_RS10035 2102236..2102862 + 627 WP_062924414.1 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(51-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13263.22 Da        Isoelectric Point: 5.9233

>T62343 WP_062924413.1 NZ_CP015099:2098616-2098960 [Glaesserella parasuis]
METEEYITFIETKVFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

>T62343 NZ_CP015099:2098616-2098960 [Glaesserella parasuis]
ATGGAAACAGAAGAATATATTACTTTTATTGAAACCAAAGTCTTTGAAGAAGATCGAAAAGCATTAATGTCTGATGATGA
ATATCAGAAATTTCAGGCTTATTTATTAGAATCTCACGAATTAGGCGATTTTATTCAGAATACTGGTGGTTGCCAAAAAA
TTCGCTGGAAACTAGAAAGTAATAACAAGGGCAAAAGTGGTGGTGTAAGGGTGATTTACTATGTTGTAACCAAACAGGGA
AAATTATTATTAATGATGATGTATGCTAAAAGCAAACAAGACAATATGAGTGATAAACAAAAAGCAATGTTAAAAGCGGT
TGTATCCCAATTAAGTGAGGAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11224.13 Da        Isoelectric Point: 10.0887

>AT62343 WP_012621770.1 NZ_CP015099:2098963-2099259 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTQHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPNLVPVLQNL

Download         Length: 297 bp

>AT62343 NZ_CP015099:2098963-2099259 [Glaesserella parasuis]
ATGGAAAAAGAACTTTTTGAACGTCTAATGGAAAGTGCGAGAGAAATGGTCGCCATTGAAAAAGGCGAAATAGAAGTACC
ACCGCATCGTATTCATATCCATAAAATCCCGAATGTCAAAGCGATTAGAACCCAGCACCAGATGAAACAAGCGGAATTTG
CTTCCCTTTTAGGTGTAAGCCAAAATCTTGTGCAGTCGTGGGAAATCGGCAGACGAACCCCAAATGGTGCGGCACGGAAA
TTGCTTGCGATTATTGAGCAACAGCCTAATCTTGTTCCAGTACTTCAGAATTTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References