Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1840444..1841048 Replicon chromosome
Accession NZ_CP015080
Organism Desulfuromonas sp. DDH964

Toxin (Protein)


Gene name higB Uniprot ID A0A143B7E5
Locus tag DBW_RS08305 Protein ID WP_066726816.1
Coordinates 1840444..1840764 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A143B763
Locus tag DBW_RS08310 Protein ID WP_066726818.1
Coordinates 1840767..1841048 (+) Length 94 a.a.

Genomic Context

DBW_RS08280DBW_RS08285DBW_RS08290DBW_RS08295DBW_RS08300DBW_RS08305DBW_RS08310DBW_RS08315DBW_RS08320DBW_RS08325DBW_RS08335DBW_RS08330DBW_RS08340
Location: 1835931..1837142 (1212 bp)
Type: Others
Protein ID: WP_066726806.1
Location: 1837196..1837789 (594 bp)
Type: Others
Protein ID: WP_066726808.1
Location: 1837782..1838090 (309 bp)
Type: Others
Protein ID: WP_066726810.1
Location: 1838087..1839298 (1212 bp)
Type: Others
Protein ID: WP_066726812.1
Location: 1839295..1840206 (912 bp)
Type: Others
Protein ID: WP_066726814.1
Location: 1840444..1840764 (321 bp)
Type: Toxin
Protein ID: WP_066726816.1
Location: 1840767..1841048 (282 bp)
Type: Antitoxin
Protein ID: WP_066726818.1
Location: 1841259..1841942 (684 bp)
Type: Others
Protein ID: WP_157471843.1
Location: 1842187..1842471 (285 bp)
Type: Others
Protein ID: WP_066726820.1
Location: 1842478..1842777 (300 bp)
Type: Others
Protein ID: WP_066726822.1
Location: 1844459..1844806 (348 bp)
Type: Others
Protein ID: WP_066729743.1
Location: 1843228..1844247 (1020 bp)
Type: Others
Protein ID: WP_066722476.1
Location: 1844952..1845605 (654 bp)
Type: Others
Protein ID: WP_082820256.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DBW_RS082801835931..1837142+1212WP_066726806.1cofactor-independent phosphoglycerate mutase-
DBW_RS082851837196..1837789+594WP_066726808.12-oxoacid:acceptor oxidoreductase family protein-
DBW_RS082901837782..1838090+309WP_066726810.14Fe-4S binding protein-
DBW_RS082951838087..1839298+1212WP_066726812.1pyruvate ferredoxin oxidoreductase-
DBW_RS083001839295..1840206+912WP_066726814.12-ketoisovalerate ferredoxin oxidoreductase-
DBW_RS083051840444..1840764+321WP_066726816.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DBW_RS083101840767..1841048+282WP_066726818.1helix-turn-helix domain-containing proteinAntitoxin
DBW_RS083151841259..1841942+684WP_157471843.1IS3 family transposase-
DBW_RS083201842187..1842471+285WP_066726820.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DBW_RS083251842478..1842777+300WP_066726822.1type II toxin-antitoxin system RelE/ParE family toxin-
DBW_RS083301843228..1844247-1020WP_066722476.1IS110 family transposase-
DBW_RS083351844459..1844806+348WP_066729743.1DUF488 domain-containing protein-
DBW_RS083401844952..1845605-654WP_082820256.1glycine zipper 2TM domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--1841319..1841942623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12418.69 Da        Isoelectric Point: 10.2633

>T62278 WP_066726816.1 NZ_CP015080:1840444-1840764 [Desulfuromonas sp. DDH964]
MRWTVEFLNEVVEEEFRELPKDMQARFVRISELIEGCGIEQVGMPHVRHLEGKLWEMRARGIAGISRGIYVAINGRRVVI
LRIFVKKTQKTPRSEILLALDRMKEL

Download         Length: 321 bp

>T62278 NZ_CP015080:1840444-1840764 [Desulfuromonas sp. DDH964]
ATGCGTTGGACCGTTGAATTTCTGAACGAGGTTGTTGAAGAAGAATTCCGTGAATTGCCCAAGGATATGCAGGCTCGGTT
CGTGCGTATCTCCGAACTGATCGAAGGTTGCGGAATCGAGCAGGTGGGAATGCCTCATGTGCGCCACCTTGAAGGTAAGC
TTTGGGAGATGCGGGCGAGGGGAATCGCTGGAATCTCCCGGGGGATTTATGTTGCGATAAACGGCAGGCGCGTGGTGATC
CTGCGAATCTTCGTGAAGAAGACCCAGAAGACGCCGCGATCGGAAATTCTGCTGGCGCTGGACCGGATGAAGGAGTTGTG
A

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10681.34 Da        Isoelectric Point: 10.3074

>AT62278 WP_066726818.1 NZ_CP015080:1840767-1841048 [Desulfuromonas sp. DDH964]
MGKKIRDLKEELLANEEFRREYQPLDEEFSIAAQLIEARTKANLTQEQVARRMGTTQSVVARLESGHPMPSLRSLRRYAL
AVGNKVEIKLVQK

Download         Length: 282 bp

>AT62278 NZ_CP015080:1840767-1841048 [Desulfuromonas sp. DDH964]
ATGGGGAAAAAGATCAGAGATTTGAAGGAAGAGTTGTTGGCCAACGAGGAATTCCGCCGTGAGTATCAGCCGCTGGACGA
GGAATTCTCCATCGCTGCACAACTGATTGAAGCTAGAACCAAGGCAAACCTCACACAGGAACAAGTGGCCAGACGCATGG
GTACTACCCAATCGGTCGTGGCACGGCTCGAGTCCGGTCATCCGATGCCGAGTTTGCGGTCCTTGCGACGGTATGCGTTG
GCGGTTGGGAACAAGGTGGAGATCAAGTTGGTTCAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A143B7E5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A143B763

References