Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1673044..1673642 Replicon chromosome
Accession NZ_CP015080
Organism Desulfuromonas sp. DDH964

Toxin (Protein)


Gene name higB Uniprot ID A0A143B6Q0
Locus tag DBW_RS07555 Protein ID WP_066726511.1
Coordinates 1673044..1673334 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A143B730
Locus tag DBW_RS07560 Protein ID WP_066726512.1
Coordinates 1673355..1673642 (+) Length 96 a.a.

Genomic Context

DBW_RS07530DBW_RS07535DBW_RS07540DBW_RS07545DBW_RS07550DBW_RS07555DBW_RS07560DBW_RS07565DBW_RS07575DBW_RS07580DBW_RS07520DBW_RS07525DBW_RS07570
Location: 1669911..1670429 (519 bp)
Type: Others
Protein ID: WP_066726497.1
Location: 1670473..1670988 (516 bp)
Type: Others
Protein ID: WP_066726499.1
Location: 1671074..1671574 (501 bp)
Type: Others
Protein ID: WP_066726501.1
Location: 1672031..1672531 (501 bp)
Type: Others
Protein ID: WP_066726507.1
Location: 1672594..1672806 (213 bp)
Type: Others
Protein ID: WP_066726510.1
Location: 1673044..1673334 (291 bp)
Type: Toxin
Protein ID: WP_066726511.1
Location: 1673355..1673642 (288 bp)
Type: Antitoxin
Protein ID: WP_066726512.1
Location: 1673804..1674013 (210 bp)
Type: Others
Protein ID: WP_066726513.1
Location: 1674746..1675186 (441 bp)
Type: Others
Protein ID: WP_066726517.1
Location: 1675276..1677024 (1749 bp)
Type: Others
Protein ID: WP_066726519.1
Location: 1668374..1669243 (870 bp)
Type: Others
Protein ID: WP_066726432.1
Location: 1669240..1669581 (342 bp)
Type: Others
Protein ID: WP_066726434.1
Location: 1674128..1674553 (426 bp)
Type: Others
Protein ID: WP_066726515.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DBW_RS075201668374..1669243-870WP_066726432.1DDE-type integrase/transposase/recombinase-
DBW_RS075251669240..1669581-342WP_066726434.1hypothetical protein-
DBW_RS075301669911..1670429+519WP_066726497.1cupin domain-containing protein-
DBW_RS075351670473..1670988+516WP_066726499.1gamma-glutamylcyclotransferase-
DBW_RS075401671074..1671574+501WP_066726501.1cytochrome C-
DBW_RS075451672031..1672531+501WP_066726507.1hypothetical protein-
DBW_RS075501672594..1672806+213WP_066726510.1hypothetical protein-
DBW_RS075551673044..1673334+291WP_066726511.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DBW_RS075601673355..1673642+288WP_066726512.1HigA family addiction module antidote proteinAntitoxin
DBW_RS075651673804..1674013+210WP_066726513.1PspC domain-containing protein-
DBW_RS075701674128..1674553-426WP_066726515.1hypothetical protein-
DBW_RS075751674746..1675186+441WP_066726517.1DUF4019 domain-containing protein-
DBW_RS075801675276..1677024+1749WP_066726519.1sigma 54-interacting transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11003.51 Da        Isoelectric Point: 7.3174

>T62277 WP_066726511.1 NZ_CP015080:1673044-1673334 [Desulfuromonas sp. DDH964]
VIASFGDKLTEALYHGTSDKDLRRLPLEIVNRTLRKLDMLNAAHDVLDLRSPPGNRLEALQGDLAGLFSIRVNDQWRIVF
RWQGGNAYEVRLTDYH

Download         Length: 291 bp

>T62277 NZ_CP015080:1673044-1673334 [Desulfuromonas sp. DDH964]
GTGATTGCATCATTTGGCGACAAGCTGACGGAAGCGCTGTATCACGGCACCAGCGACAAAGACCTTCGTCGGCTGCCGTT
GGAAATCGTCAACCGCACCCTTCGCAAACTCGACATGCTCAATGCCGCCCACGATGTTCTGGATCTGCGCTCTCCCCCGG
GTAATCGCCTGGAAGCGTTGCAGGGAGACCTTGCGGGACTGTTCAGTATCCGGGTCAACGACCAATGGCGGATCGTGTTT
CGCTGGCAGGGCGGTAACGCCTACGAAGTGCGCCTGACCGATTATCACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10806.49 Da        Isoelectric Point: 8.6797

>AT62277 WP_066726512.1 NZ_CP015080:1673355-1673642 [Desulfuromonas sp. DDH964]
MIPENRIPSHPGKILKEEFLDELGVSQVAFAAHIKVPVQRVNEIVRGKRGITSDTAWLLAQALDTTPEFWLNLQGTYDLA
LNRPERRIEKLRMAS

Download         Length: 288 bp

>AT62277 NZ_CP015080:1673355-1673642 [Desulfuromonas sp. DDH964]
ATGATCCCTGAAAACCGCATCCCGTCCCATCCCGGGAAAATCCTCAAGGAAGAGTTCCTCGACGAACTCGGCGTCAGCCA
AGTTGCGTTCGCCGCGCACATCAAGGTTCCGGTTCAACGCGTCAACGAGATCGTCCGGGGCAAGCGCGGCATCACCTCGG
ATACCGCCTGGCTACTGGCGCAGGCTCTCGATACCACCCCCGAGTTCTGGCTCAACCTACAGGGGACTTACGACCTGGCA
CTGAACCGTCCGGAAAGGAGAATCGAGAAACTGCGCATGGCCAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A143B6Q0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A143B730

References