62210

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 842084..843402 Replicon chromosome
Accession NZ_CP015074
Organism Escherichia coli strain Ecol_745

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag A4R38_RS04035 Protein ID WP_001262467.1
Coordinates 842395..843402 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag A4R38_RS04030 Protein ID WP_001312177.1
Coordinates 842084..842395 (+) Length 104 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R38_RS04005 837616..838635 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
A4R38_RS04010 838645..839547 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
A4R38_RS04015 839558..840541 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
A4R38_RS04020 840538..841551 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
A4R38_RS04025 841776..842099 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
A4R38_RS04030 842084..842395 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
A4R38_RS04035 842395..843402 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
A4R38_RS04040 843419..844690 - 1272 WP_001545666.1 amino acid permease -
- 845052..845117 - 66 NuclAT_27 - -
- 845052..845117 - 66 NuclAT_27 - -
- 845052..845117 - 66 NuclAT_27 - -
- 845052..845117 - 66 NuclAT_27 - -
A4R38_RS26935 845166..845273 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- 845535..845592 - 58 NuclAT_26 - -
- 845535..845592 - 58 NuclAT_26 - -
- 845535..845592 - 58 NuclAT_26 - -
- 845535..845592 - 58 NuclAT_26 - -
A4R38_RS27495 845649..845756 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
A4R38_RS26950 846132..846239 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
A4R38_RS04065 846325..848004 - 1680 Protein_753 cellulose biosynthesis protein BcsG -
A4R38_RS04070 848001..848192 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(56-302)

Antitoxin

(6-98)


Sequences


Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T62210 WP_001262467.1 NZ_CP015074:842395-843402 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

>T62210 NZ_CP015074:842395-843402 [Escherichia coli]
ATGGCGAATTGTCGTATTCTGTTAACGCCGTTGAATGAACGTGACGAACAGCGCGGATATTCGACACAGGGGTTGAAGCG
ACTGAGCGGCACTGCAAAATTGACCCCCAGGCTGGGGTTTACGCGAACTCAGTTTGTGCAGGAACTTCCGCGTCAACAAA
AAGGGATGAGTATTTCCGGTTACCAGCCCAAATTGCAATTAGTGCTGGATGAAGGAGAGTTCCGCGTCGTAGATCATCAG
GGAAATTTTATCCTTAAGCCCTCTCCAGCCGACTTTCCCGGTTTGGCCGAAAATGAACACGCAACAATGACATTGATGTC
TCGTTTGGGATTTGACGTACCTGTGCATGGCCTGTTGAGTTTTGCACCACAATCAGAGGAAGAGCTTGAATACGCATTTG
TTATCCGGCGCTATGACCGGGATAACAAGGGGCTGCCAGTGCATCAGGAACAGCTTGATGGCGCGATGCAGATTATGGAT
AAATATGGCAAAACGGGGAATGATAACGAACAATATGTCAGCTATGAAACGCTGGCCCGATTTTTAGTTGCCCATGTTAA
CGACAACATCGCATTTAAAATCGATCTCTTTCGTCGCATTGTTTACGCCTGGTTGCTGGGTAATAACGACATGCATTTAC
GAAACTTTGGCTTAGTGTACTCCGATGGTTTGACGCCAGCGTTAGCGCCGGTGTATGACTTTGTTTCTGTCGCTCCCTAT
CCGGAATATTTTCACTCAAACTATCTGGCGCTGCCGTTATTGACGCGAGAAGAAGGCGGTCGGGAGCTGGCTCCTGGATT
TCACAGTGATTATGGCGAGTATATCGGGCAGGACTTTTTGCTGTTGGGTGAATCAATGGGGTTAGCGCCCAGATTGCTGG
AAAAACTCTTTCAGGATATACGTAAAGAAAATGCCATTGTTATGGAAACGTATGAGCAGTCCTTTATGACTCAGGATCAT
ATCCAGGCTGTGCTGCAATGCTATCGACATCGTCTGGGGCTGCTGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT62210 WP_001312177.1 NZ_CP015074:842084-842395 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp

>AT62210 NZ_CP015074:842084-842395 [Escherichia coli]
ATGCATCGGCGAGTGAAAGTGTTGCTCTATGGTCAGGTAGTGGGTGAACTCTCTCAGAACGACAGTGGTTTTTTGTTCCA
GTATGCCCCGGATTACCACGGACCGGCAATCTCAATCAGCCTGCCCGTCGCACAGCGTCAGTTTCCCAGTGAGATGTTGC
ATCCTTATTTCGCCTCACTGGCGCCAGAAGGATGGCTGCGTCAACGCTACAGCCAGATACAGCATCGTGACGAAAACGAT
CTGCTGGGAATGCTTATTGATAACGGCAAGAATCTGCTGGGGGCCATCCAGATTTTACCTTGGGAGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5


Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References