Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2607616..2607838 Replicon chromosome
Accession NZ_CP015069
Organism Escherichia coli strain Ecol_743

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag A4R39_RS27910 Protein ID WP_001295224.1
Coordinates 2607616..2607723 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2607772..2607838 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R39_RS12810 2602668..2602856 - 189 WP_001063314.1 YhjR family protein -
A4R39_RS12815 2603129..2604700 + 1572 WP_001204941.1 cellulose biosynthesis protein BcsE -
A4R39_RS12820 2604697..2604888 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
A4R39_RS12825 2604885..2606564 + 1680 Protein_2447 cellulose biosynthesis protein BcsG -
A4R39_RS27900 2606650..2606757 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
A4R39_RS28505 2607133..2607240 - 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
A4R39_RS27910 2607616..2607723 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 2607772..2607838 + 67 - - Antitoxin
A4R39_RS12850 2608199..2609470 + 1272 WP_001545666.1 amino acid permease -
A4R39_RS12855 2609487..2610494 - 1008 WP_001262467.1 HipA domain-containing protein -
A4R39_RS12860 2610494..2610805 - 312 WP_001312177.1 HipA N-terminal domain-containing protein -
A4R39_RS12865 2610790..2611113 - 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
A4R39_RS12870 2611338..2612351 - 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T62184 WP_001295224.1 NZ_CP015069:c2607723-2607616 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T62184 NZ_CP015069:c2607723-2607616 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT62184 NZ_CP015069:2607772-2607838 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7

Antitoxin

Download structure file

References