Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1092460..1093149 Replicon chromosome
Accession NZ_CP015030
Organism Mannheimia granulomatis strain B 234/94

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A4G16_RS05255 Protein ID WP_165888999.1
Coordinates 1092772..1093149 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A4G16_RS05250 Protein ID WP_165888998.1
Coordinates 1092460..1092771 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4G16_RS05230 1090082..1090576 + 495 WP_165888994.1 hypothetical protein -
A4G16_RS05235 1090619..1091644 + 1026 WP_165888995.1 DNA polymerase III subunit delta -
A4G16_RS05240 1091646..1091831 - 186 WP_165888996.1 DNA gyrase inhibitor YacG -
A4G16_RS05245 1091816..1092451 - 636 WP_165888997.1 dephospho-CoA kinase -
A4G16_RS05250 1092460..1092771 - 312 WP_165888998.1 XRE family transcriptional regulator Antitoxin
A4G16_RS05255 1092772..1093149 - 378 WP_165888999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4G16_RS05260 1093192..1093827 - 636 WP_165889000.1 prepilin peptidase -
A4G16_RS05265 1093831..1095027 - 1197 WP_165889001.1 type II secretion system F family protein -
A4G16_RS05270 1095020..1096414 - 1395 WP_165889002.1 GspE/PulE family protein -
A4G16_RS05275 1096437..1096907 - 471 WP_165889003.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(24-117)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14778.23 Da        Isoelectric Point: 8.4523

>T62132 WP_165888999.1 NZ_CP015030:c1093149-1092772 [Mannheimia granulomatis]
MKELNLDDPTFKWELLVTDCFYFWLCEQDKGTKNCILSALERLRLFGPYLARPYADHIKGSNYKNMKELRVQYQGKVIRA
FFAFDPLRKAIVLCAGDKSNDKLFYEKMLKLADKEFKNYLASLEE

Download         Length: 378 bp

>T62132 NZ_CP015030:c1093149-1092772 [Mannheimia granulomatis]
ATGAAAGAGCTTAACTTAGACGATCCTACTTTCAAATGGGAGTTATTAGTTACCGATTGCTTCTATTTTTGGTTATGTGA
GCAAGACAAAGGTACGAAAAATTGTATATTGTCGGCTTTGGAGAGATTGAGGCTTTTTGGCCCGTATCTTGCTAGACCTT
ACGCAGATCATATAAAAGGATCTAATTATAAAAATATGAAGGAATTGCGTGTACAGTATCAGGGAAAAGTTATAAGAGCT
TTCTTTGCTTTTGATCCACTCAGAAAAGCAATAGTACTCTGTGCTGGGGATAAAAGTAATGACAAATTATTTTATGAAAA
AATGCTTAAATTAGCGGATAAGGAATTTAAAAATTATTTAGCTAGTTTGGAGGAATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11548.39 Da        Isoelectric Point: 4.8952

>AT62132 WP_165888998.1 NZ_CP015030:c1092771-1092460 [Mannheimia granulomatis]
MANKLRTLDEVIAELPQDQQDEIHRMAEELILEAGLSMLREDLEISQKELAKALGVSQPAVVQMEQRGNDIKLSTLKRYV
EAMGGKLSLAVQMPTGNSRIFRI

Download         Length: 312 bp

>AT62132 NZ_CP015030:c1092771-1092460 [Mannheimia granulomatis]
ATGGCTAATAAACTAAGAACATTAGATGAAGTAATTGCTGAGCTACCACAGGATCAGCAAGATGAAATACATCGAATGGC
GGAAGAACTGATTTTAGAAGCTGGGCTTTCTATGCTGCGTGAAGATCTGGAAATTTCTCAAAAAGAGCTGGCGAAGGCAT
TGGGTGTTTCACAGCCGGCAGTTGTTCAGATGGAACAGAGAGGTAATGATATTAAACTCTCTACCTTAAAGCGTTATGTG
GAAGCGATGGGTGGCAAGCTAAGTCTTGCGGTGCAAATGCCGACAGGTAACAGCCGTATTTTCAGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References