Detailed information of TA system TA062094

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 2526724..2526945
• Replicon: chromosome
• Accession: NZ_CP015023
• Organism: Escherichia coli strain SRCC 1675

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: AR439_RS31805
• Protein ID: WP_001295224.1
• Coordinates: 2526724..2526831 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	2526880..2526945 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AR439_RS13615	2521977..2522729	-	753	Protein_2500	cellulose biosynthesis protein BcsQ	-
AR439_RS13625	2522741..2522929	-	189	WP_001063316.1	YhjR family protein	-
AR439_RS13630	2523202..2524773	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
AR439_RS13635	2524770..2524961	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
AR439_RS13640	2524958..2526637	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
AR439_RS31805	2526724..2526831	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2526880..2526945	+	66	NuclAT_17	-	Antitoxin
-	2526880..2526945	+	66	NuclAT_17	-	Antitoxin
-	2526880..2526945	+	66	NuclAT_17	-	Antitoxin
-	2526880..2526945	+	66	NuclAT_17	-	Antitoxin
-	2526880..2526945	+	66	NuclAT_22	-	Antitoxin
-	2526880..2526945	+	66	NuclAT_22	-	Antitoxin
-	2526880..2526945	+	66	NuclAT_22	-	Antitoxin
-	2526880..2526945	+	66	NuclAT_22	-	Antitoxin
AR439_RS13655	2527307..2528578	+	1272	WP_001301684.1	amino acid permease	-
AR439_RS13660	2528608..2529612	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
AR439_RS13665	2529609..2530592	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
AR439_RS13670	2530603..2531505	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T62094 WP_001295224.1 NZ_CP015023:c2526831-2526724 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T62094 NZ_CP015023:c2526831-2526724 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT62094 NZ_CP015023:2526880-2526945 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin