Detailed information of TA system TA062052

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 2729364..2729585
• Replicon: chromosome
• Accession: NZ_CP015020
• Organism: Escherichia coli strain 28RC1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: ARC77_RS31840
• Protein ID: WP_001295224.1
• Coordinates: 2729364..2729471 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	2729520..2729585 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ARC77_RS14225	2724617..2725369	-	753	Protein_2708	cellulose biosynthesis protein BcsQ	-
ARC77_RS14235	2725381..2725569	-	189	WP_001063316.1	YhjR family protein	-
ARC77_RS14240	2725842..2727413	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
ARC77_RS14245	2727410..2727601	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
ARC77_RS14250	2727598..2729277	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
ARC77_RS31840	2729364..2729471	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2729520..2729585	+	66	NuclAT_16	-	Antitoxin
-	2729520..2729585	+	66	NuclAT_16	-	Antitoxin
-	2729520..2729585	+	66	NuclAT_16	-	Antitoxin
-	2729520..2729585	+	66	NuclAT_16	-	Antitoxin
-	2729520..2729585	+	66	NuclAT_21	-	Antitoxin
-	2729520..2729585	+	66	NuclAT_21	-	Antitoxin
-	2729520..2729585	+	66	NuclAT_21	-	Antitoxin
-	2729520..2729585	+	66	NuclAT_21	-	Antitoxin
ARC77_RS14265	2729947..2731218	+	1272	WP_001301684.1	amino acid permease	-
ARC77_RS14270	2731248..2732252	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
ARC77_RS14275	2732249..2733232	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
ARC77_RS14280	2733243..2734145	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T62052 WP_001295224.1 NZ_CP015020:c2729471-2729364 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T62052 NZ_CP015020:c2729471-2729364 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT62052 NZ_CP015020:2729520-2729585 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin