Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 547146..547710 Replicon chromosome
Accession NZ_CP014985
Organism Lacticaseibacillus paracasei strain IIA

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag A3778_RS02705 Protein ID WP_016363448.1
Coordinates 547146..547448 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag A3778_RS02710 Protein ID WP_003570051.1
Coordinates 547441..547710 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3778_RS02690 542459..543016 + 558 WP_003584278.1 helix-turn-helix domain-containing protein -
A3778_RS02695 543441..545618 - 2178 WP_003570057.1 RNA-binding transcriptional accessory protein -
A3778_RS02700 545854..546546 - 693 WP_003570055.1 hypothetical protein -
A3778_RS17125 546664..546807 - 144 WP_162259784.1 hypothetical protein -
A3778_RS02705 547146..547448 - 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
A3778_RS02710 547441..547710 - 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A3778_RS02715 548084..548737 - 654 WP_003570049.1 GNAT family N-acetyltransferase -
A3778_RS02720 548782..549411 - 630 WP_003570047.1 DUF2399 domain-containing protein -
A3778_RS02725 549474..549800 - 327 WP_003584272.1 YrdB family protein -
A3778_RS02730 549793..550197 - 405 WP_003570045.1 MerR family transcriptional regulator -
A3778_RS02735 550395..551621 + 1227 WP_003570043.1 hypothetical protein -
A3778_RS02740 551818..552705 + 888 WP_003570041.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T61954 WP_016363448.1 NZ_CP014985:c547448-547146 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

>T61954 NZ_CP014985:c547448-547146 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCCGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCCT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTATATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTGAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGTTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT61954 WP_003570051.1 NZ_CP014985:c547710-547441 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT61954 NZ_CP014985:c547710-547441 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAGGAAACTCGCTTGAATATTCGTGTTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References