Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 15463..16120 | Replicon | plasmid pSTY1-1896 |
| Accession | NZ_CP014978 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium str. USDA-ARS-USMARC-1896 isolate ST03-F34 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | AW99_RS23680 | Protein ID | WP_000270043.1 |
| Coordinates | 15770..16120 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | AW99_RS23675 | Protein ID | WP_000124640.1 |
| Coordinates | 15463..15765 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AW99_RS23625 | 11088..11516 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| AW99_RS23630 | 11573..11932 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| AW99_RS23635 | 11932..12378 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| AW99_RS23640 | 12375..12893 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| AW99_RS23645 | 12893..13123 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| AW99_RS23650 | 13110..13967 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| AW99_RS23660 | 14198..14725 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| AW99_RS23665 | 14783..15055 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| AW99_RS23670 | 15143..15436 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| AW99_RS23675 | 15463..15765 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| AW99_RS23680 | 15770..16120 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AW99_RS23685 | 16283..16831 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| AW99_RS26395 | 17172..17366 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| AW99_RS26400 | 17377..17748 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| AW99_RS23705 | 17741..18211 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| AW99_RS23710 | 18226..18561 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| AW99_RS23715 | 18658..19146 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| AW99_RS23720 | 19149..19646 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| AW99_RS23725 | 19861..20565 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| AW99_RS23730 | 20630..20809 | - | 180 | Protein_34 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..147296 | 147296 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 17237.68 Da Isoelectric Point: 5.5500
>T61952 WP_000270043.1 NZ_CP014978:c16120-15770 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 351 bp
>T61952 NZ_CP014978:c16120-15770 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
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Antitoxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>AT61952 WP_000124640.1 NZ_CP014978:c15765-15463 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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Download Length: 303 bp
>AT61952 NZ_CP014978:c15765-15463 [Salmonella enterica subsp. enterica serovar Typhimurium str.]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|