Detailed information of TA system TA061940

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 1805524..1805861
• Replicon: chromosome
• Accession: NZ_CP014949
• Organism: Enterococcus faecalis strain LD33

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: A3777_RS08905
• Protein ID: WP_002381035.1
• Coordinates: 1805524..1805667 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	1805599..1805861 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A3777_RS08890	1801616..1802254	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
A3777_RS08900	1802940..1804556	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
A3777_RS14240	1804885..1805034	+	150	WP_002411240.1	putative holin-like toxin	-
A3777_RS14245	1805153..1805293	+	141	WP_073340360.1	putative holin-like toxin	-
A3777_RS08905	1805524..1805667	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	1805599..1805861	-	263	-	-	Antitoxin
A3777_RS08910	1805862..1809689	-	3828	WP_010816211.1	WxL domain-containing protein	-
A3777_RS08915	1809676..1810038	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T61940 WP_002381035.1 NZ_CP014949:1805524-1805667 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T61940 NZ_CP014949:1805524-1805667 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT61940 NZ_CP014949:c1805861-1805599 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin