Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 1804967..1805293 Replicon chromosome
Accession NZ_CP014949
Organism Enterococcus faecalis strain LD33

Toxin (Protein)


Gene name txpA Uniprot ID A0A3N3Z2N6
Locus tag A3777_RS14245 Protein ID WP_073340360.1
Coordinates 1805153..1805293 (+) Length 47 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 1804967..1805151 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3777_RS08880 1800006..1800221 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
A3777_RS08885 1800360..1801352 + 993 WP_002389493.1 biotin--[acetyl-CoA-carboxylase] ligase -
A3777_RS08890 1801616..1802254 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
A3777_RS08900 1802940..1804556 + 1617 WP_002389442.1 phosphatase PAP2/LCP family protein -
A3777_RS14240 1804885..1805034 + 150 WP_002411240.1 putative holin-like toxin -
- 1804967..1805151 - 185 - - Antitoxin
A3777_RS14245 1805153..1805293 + 141 WP_073340360.1 putative holin-like toxin Toxin
A3777_RS08905 1805524..1805667 + 144 WP_002381035.1 putative holin-like toxin -
A3777_RS08910 1805862..1809689 - 3828 WP_010816211.1 WxL domain-containing protein -
A3777_RS08915 1809676..1810038 - 363 WP_002378868.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-46)


Sequences

Toxin        


Download         Length: 47 a.a.        Molecular weight: 5218.33 Da        Isoelectric Point: 10.3265

>T61931 WP_073340360.1 NZ_CP014949:1805153-1805293 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 141 bp

>T61931 NZ_CP014949:1805153-1805293 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 185 bp

>AT61931 NZ_CP014949:c1805151-1804967 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N3Z2N6

Antitoxin

Download structure file

References