Detailed information of TA system TA061928

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1804885..1805151
• Replicon: chromosome
• Accession: NZ_CP014949
• Organism: Enterococcus faecalis strain LD33

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: A3777_RS14240
• Protein ID: WP_002411240.1
• Coordinates: 1804885..1805034 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1804967..1805151 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A3777_RS08880	1800006..1800221	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
A3777_RS08885	1800360..1801352	+	993	WP_002389493.1	biotin--[acetyl-CoA-carboxylase] ligase	-
A3777_RS08890	1801616..1802254	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
A3777_RS08900	1802940..1804556	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
A3777_RS14240	1804885..1805034	+	150	WP_002411240.1	putative holin-like toxin	Toxin
-	1804967..1805151	-	185	-	-	Antitoxin
A3777_RS14245	1805153..1805293	+	141	WP_073340360.1	putative holin-like toxin	-
A3777_RS08905	1805524..1805667	+	144	WP_002381035.1	putative holin-like toxin	-
A3777_RS08910	1805862..1809689	-	3828	WP_010816211.1	WxL domain-containing protein	-
A3777_RS08915	1809676..1810038	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (16-49)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5738.05 Da
• Isoelectric Point: 11.3858

>T61928 WP_002411240.1 NZ_CP014949:1804885-1805034 [Enterococcus faecalis]
MRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 150 bp

>T61928 NZ_CP014949:1804885-1805034 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT61928 NZ_CP014949:c1805151-1804967 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin