Detailed information of TA system TA061924

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1732026..1732288
• Replicon: chromosome
• Accession: NZ_CP014949
• Organism: Enterococcus faecalis strain LD33

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: A3777_RS14215
• Protein ID: WP_002367458.1
• Coordinates: 1732145..1732288 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1732026..1732212 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A3777_RS08560	1727483..1730227	+	2745	WP_062775452.1	glycoside hydrolase family 65 protein	-
A3777_RS08565	1730242..1730892	+	651	WP_002389419.1	beta-phosphoglucomutase	-
A3777_RS08570	1731312..1731905	+	594	WP_002389391.1	hypothetical protein	-
-	1732026..1732212	+	187	-	-	Antitoxin
A3777_RS14215	1732145..1732288	-	144	WP_002367458.1	putative holin-like toxin	Toxin
A3777_RS08575	1732520..1733491	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
A3777_RS08580	1733666..1734103	-	438	WP_002389480.1	peptide-methionine (R)-S-oxide reductase MsrB	-
A3777_RS08585	1734236..1734790	-	555	WP_002354869.1	septum formation protein Maf	-
A3777_RS08590	1734815..1736947	-	2133	WP_002389406.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5311.50 Da
• Isoelectric Point: 10.8331

>T61924 WP_002367458.1 NZ_CP014949:c1732288-1732145 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T61924 NZ_CP014949:c1732288-1732145 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 187 bp

>AT61924 NZ_CP014949:1732026-1732212 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin