Detailed information of TA system TA061920

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1660916..1661202
• Replicon: chromosome
• Accession: NZ_CP014949
• Organism: Enterococcus faecalis strain LD33

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: A3777_RS08245
• Protein ID: WP_002393909.1
• Coordinates: 1661074..1661202 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1660916..1661125 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A3777_RS08215	1656169..1657122	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
A3777_RS08220	1657161..1657916	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
A3777_RS08225	1657913..1658878	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
A3777_RS08230	1658875..1659822	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
A3777_RS08235	1660007..1660459	+	453	WP_002389410.1	YueI family protein	-
A3777_RS08240	1660641..1660768	-	128	Protein_1571	putative holin-like toxin	-
-	1660916..1661125	+	210	-	-	Antitoxin
A3777_RS08245	1661074..1661202	-	129	WP_002393909.1	hypothetical protein	Toxin
A3777_RS08250	1661365..1663635	-	2271	WP_002389492.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
A3777_RS08255	1663806..1664306	+	501	WP_002372831.1	cysteine hydrolase	-
A3777_RS08260	1664705..1665601	+	897	WP_002389477.1	YitT family protein	-
A3777_RS08265	1665652..1666050	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T61920 WP_002393909.1 NZ_CP014949:c1661202-1661074 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T61920 NZ_CP014949:c1661202-1661074 [Enterococcus faecalis]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 210 bp

>AT61920 NZ_CP014949:1660916-1661125 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin