61918

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5341166..5341761 Replicon chromosome
Accession NZ_CP014948
Organism Pseudomonas aeruginosa strain N17-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OB07_RS30325 Protein ID WP_071538299.1
Coordinates 5341483..5341761 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OB07_RS24760 Protein ID WP_003123432.1
Coordinates 5341166..5341471 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OB07_RS24725 5336306..5337154 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
OB07_RS24735 5337321..5338262 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
OB07_RS24740 5338379..5338993 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
OB07_RS24745 5339035..5339619 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
OB07_RS24750 5339660..5340760 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
OB07_RS24760 5341166..5341471 - 306 WP_003123432.1 HigA family addiction module antidote protein Antitoxin
OB07_RS30325 5341483..5341761 - 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OB07_RS24765 5342090..5344318 + 2229 WP_003113525.1 TonB-dependent receptor -
OB07_RS24770 5344388..5345035 - 648 WP_003095021.1 carbonate dehydratase -
OB07_RS24775 5345097..5346335 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T61918 WP_071538299.1 NZ_CP014948:c5341761-5341483 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T61918 NZ_CP014948:c5341761-5341483 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAAGGAAAGCGGGCGGGCCAACATGGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT61918 WP_003123432.1 NZ_CP014948:c5341471-5341166 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT61918 NZ_CP014948:c5341471-5341166 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References