Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) orf9-orf10/-
Location 5941..7325 Replicon plasmid unnamed
Accession NZ_CP014857
Organism Lysinibacillus sphaericus strain III(3)7

Toxin (Protein)


Gene name ORF9 Uniprot ID -
Locus tag A1T07_RS22675 Protein ID WP_012291646.1
Coordinates 6780..7325 (-) Length 182 a.a.

Antitoxin (Protein)


Gene name ORF10 Uniprot ID B1I081
Locus tag A1T07_RS22670 Protein ID WP_012291647.1
Coordinates 5941..6780 (-) Length 280 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1T07_RS22640 2505..3035 - 531 WP_062794086.1 hypothetical protein -
A1T07_RS24785 3032..3349 - 318 WP_196764895.1 hypothetical protein -
A1T07_RS22650 3286..3546 - 261 WP_062794088.1 hypothetical protein -
A1T07_RS22655 3987..4355 - 369 WP_031417274.1 hypothetical protein -
A1T07_RS22660 4643..4918 - 276 WP_041659272.1 hypothetical protein -
A1T07_RS22665 4963..5814 - 852 WP_061504576.1 hypothetical protein -
A1T07_RS22670 5941..6780 - 840 WP_012291647.1 hypothetical protein Antitoxin
A1T07_RS22675 6780..7325 - 546 WP_012291646.1 NYN domain-containing protein Toxin
A1T07_RS22680 7546..8034 - 489 WP_012291645.1 hypothetical protein -
A1T07_RS22685 8074..8625 - 552 WP_145912405.1 ATP-binding protein -
A1T07_RS22690 8612..8887 - 276 WP_031417270.1 DUF1292 domain-containing protein -
A1T07_RS22695 8898..10034 - 1137 WP_012291642.1 hypothetical protein -
A1T07_RS22700 10038..11132 - 1095 WP_041659270.1 hypothetical protein -
A1T07_RS22705 11321..12076 - 756 WP_012291640.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..173793 173793


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

NYN domain

(4-158)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 182 a.a.        Molecular weight: 20304.38 Da        Isoelectric Point: 9.4376

>T61845 WP_012291646.1 NZ_CP014857:c7325-6780 [Lysinibacillus sphaericus]
MKKTAILVDEMNVIQQLRRLGIHGFNPWNAFYQALQRWNGDKKGVKAFYCANVPKEDAEHEKRNNFFEGLINHNIKVSVG
TVVYDSNSRRIAKGVDVALALDIVEHARSGVQDIFICTGDADVVPAIIRAQELGSRVHVVVSRAIPAKNITLAADSVVRL
EDILETMPPHRIKYFAKERVS

Download         Length: 546 bp

>T61845 NZ_CP014857:c7325-6780 [Lysinibacillus sphaericus]
ATGAAAAAGACAGCTATTTTAGTAGATGAAATGAACGTGATTCAACAACTCCGACGTTTAGGAATCCATGGATTCAATCC
CTGGAATGCATTTTATCAGGCGTTACAACGTTGGAATGGTGATAAGAAAGGTGTTAAAGCATTTTATTGTGCTAACGTAC
CTAAAGAAGATGCAGAACATGAAAAGCGTAATAATTTCTTTGAAGGATTAATAAATCATAACATCAAAGTATCAGTAGGT
ACTGTTGTATATGACTCAAACTCAAGACGGATAGCAAAAGGTGTAGATGTTGCCTTAGCGCTGGACATAGTAGAACATGC
TAGAAGCGGTGTACAAGATATTTTCATCTGTACAGGTGATGCTGATGTTGTGCCTGCCATTATTCGCGCACAGGAGCTCG
GTAGTCGTGTTCACGTTGTAGTTTCCAGGGCTATCCCAGCTAAAAATATCACCCTTGCAGCTGATTCAGTGGTTAGATTA
GAGGATATCTTAGAAACCATGCCTCCTCACCGCATTAAATACTTTGCTAAGGAGCGTGTGAGCTAA

Antitoxin


Download         Length: 280 a.a.        Molecular weight: 31528.09 Da        Isoelectric Point: 5.2827

>AT61845 WP_012291647.1 NZ_CP014857:c6780-5941 [Lysinibacillus sphaericus]
METAPQEIFDLTLAKKTENEKELENAYRRIPDEYHDFIVLLEQKIKITDSRYFLAEEFITMGAYQDEKGIYLKIKKPYMT
VDGRIRMARDEHSKKEAKLIISEPQIIQVGNRICMNVTVESEIHGTATGTIEVNINGFGVDKKNPVANAQTSALGRALGF
LGYGIIGTAATASLDEATNLYNSLFASPSKEQVDPKKPEIKRVRICGPIEYKNNDLGYVQIQLETEEYVIMQIGKSLFRY
ENILVTNAVVKVRGWWNGEIFAAAPDQDIILDQNKKIVS

Download         Length: 840 bp

>AT61845 NZ_CP014857:c6780-5941 [Lysinibacillus sphaericus]
ATGGAGACAGCGCCACAAGAGATATTTGACCTTACACTTGCCAAAAAGACTGAAAATGAAAAGGAATTAGAGAATGCTTA
CAGAAGGATTCCGGATGAATACCATGACTTTATTGTATTGCTGGAGCAAAAAATTAAAATTACTGATAGTAGATACTTTT
TAGCAGAGGAATTTATAACAATGGGTGCCTACCAAGACGAAAAAGGTATCTATTTAAAGATTAAAAAGCCGTATATGACT
GTTGATGGCCGTATTCGAATGGCTCGCGATGAACATTCTAAAAAGGAAGCCAAACTAATTATTTCTGAACCTCAAATTAT
ACAAGTGGGAAATCGAATTTGTATGAATGTGACAGTTGAAAGTGAAATCCATGGCACTGCTACAGGAACTATAGAGGTTA
ATATTAACGGTTTTGGGGTAGATAAGAAGAATCCTGTAGCTAACGCACAAACTAGCGCTTTAGGACGTGCATTAGGCTTT
TTAGGGTACGGTATTATAGGTACTGCAGCAACCGCTTCATTAGATGAGGCTACAAACCTATATAACTCTTTATTTGCTTC
TCCAAGTAAGGAACAAGTTGATCCAAAGAAACCCGAGATTAAACGAGTTAGAATTTGTGGACCGATCGAATATAAAAACA
ACGACTTAGGGTATGTTCAAATACAGCTAGAAACTGAGGAATATGTAATAATGCAAATTGGAAAAAGCTTATTCAGATAT
GAAAATATACTGGTAACAAATGCAGTAGTAAAGGTGCGTGGTTGGTGGAACGGTGAAATATTCGCAGCTGCACCTGACCA
GGATATTATCTTGGACCAAAATAAAAAGATTGTTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6H0A0V0

References