Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1609329..1609938 Replicon chromosome
Accession NZ_CP014841
Organism Dyella thiooxydans strain ATSB10

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ATSB10_RS18925 Protein ID WP_083966132.1
Coordinates 1609329..1609607 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ATSB10_RS18930 Protein ID WP_083966133.1
Coordinates 1609627..1609938 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATSB10_RS07320 1605121..1607541 - 2421 WP_063671699.1 TonB-dependent receptor -
ATSB10_RS18915 1607704..1608066 + 363 WP_083966130.1 helix-turn-helix transcriptional regulator -
ATSB10_RS18920 1608213..1608467 + 255 WP_083966131.1 helix-turn-helix domain-containing protein -
ATSB10_RS18925 1609329..1609607 + 279 WP_083966132.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ATSB10_RS18930 1609627..1609938 + 312 WP_083966133.1 HigA family addiction module antidote protein Antitoxin
ATSB10_RS19325 1610658..1611575 - 918 WP_157469154.1 hypothetical protein -
ATSB10_RS07325 1611758..1613440 - 1683 WP_063671701.1 DUF262 domain-containing protein -
ATSB10_RS07330 1613442..1614485 - 1044 WP_063671703.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1583574..1620999 37425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(30-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10702.13 Da        Isoelectric Point: 6.7014

>T61837 WP_083966132.1 NZ_CP014841:1609329-1609607 [Dyella thiooxydans]
MIHSVSGPLAKELYSGQCPKELELCRTTAERKLTYLDSVVTLEALRYPPGNRLEKLMGNRTGQYSIRINDQYRICFRWEN
DGPHDVEITDYH

Download         Length: 279 bp

>T61837 NZ_CP014841:1609329-1609607 [Dyella thiooxydans]
ATGATCCACTCTGTATCAGGCCCCCTGGCTAAGGAGCTCTATTCCGGGCAGTGTCCTAAGGAACTCGAGCTATGCAGGAC
CACAGCCGAGCGCAAGCTTACCTACCTTGACTCCGTTGTTACGCTCGAAGCGCTTAGGTATCCACCTGGAAATCGACTAG
AAAAATTAATGGGAAATCGGACTGGTCAGTACAGCATCAGGATCAATGATCAGTATCGCATCTGCTTCCGTTGGGAGAAT
GACGGGCCGCATGATGTGGAGATAACCGACTACCATTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11612.43 Da        Isoelectric Point: 7.4046

>AT61837 WP_083966133.1 NZ_CP014841:1609627-1609938 [Dyella thiooxydans]
MVKNGMRAIHPGEILREDFLPGYDMSPNALAQALRVPATRIHAIVNEKRAITADTALRLGRLFATGPDVWMNLQAKFDLR
KAEIEFGEIVEHDVRPIEQRHVG

Download         Length: 312 bp

>AT61837 NZ_CP014841:1609627-1609938 [Dyella thiooxydans]
ATGGTTAAAAATGGCATGCGTGCCATTCATCCAGGGGAGATTCTCAGGGAAGATTTTCTCCCCGGCTATGACATGTCGCC
AAACGCCTTGGCACAGGCTCTTCGTGTTCCGGCGACTCGAATTCACGCGATTGTTAACGAGAAGCGAGCAATCACGGCGG
ATACAGCCCTACGTCTCGGCCGACTGTTCGCAACCGGCCCCGACGTGTGGATGAACTTGCAGGCAAAATTCGATCTACGT
AAAGCGGAAATTGAGTTTGGCGAAATTGTTGAGCATGATGTCCGCCCGATCGAGCAACGACACGTCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References