Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1609329..1609938 Replicon chromosome
Accession NZ_CP014841
Organism Dyella thiooxydans strain ATSB10

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ATSB10_RS18925 Protein ID WP_083966132.1
Coordinates 1609329..1609607 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ATSB10_RS18930 Protein ID WP_083966133.1
Coordinates 1609627..1609938 (+) Length 104 a.a.

Genomic Context

ATSB10_RS18915ATSB10_RS18920ATSB10_RS18925ATSB10_RS18930ATSB10_RS07320ATSB10_RS19325ATSB10_RS07325ATSB10_RS07330
Location: 1607704..1608066 (363 bp)
Type: Others
Protein ID: WP_083966130.1
Location: 1608213..1608467 (255 bp)
Type: Others
Protein ID: WP_083966131.1
Location: 1609329..1609607 (279 bp)
Type: Toxin
Protein ID: WP_083966132.1
Location: 1609627..1609938 (312 bp)
Type: Antitoxin
Protein ID: WP_083966133.1
Location: 1605121..1607541 (2421 bp)
Type: Others
Protein ID: WP_063671699.1
Location: 1610658..1611575 (918 bp)
Type: Others
Protein ID: WP_157469154.1
Location: 1611758..1613440 (1683 bp)
Type: Others
Protein ID: WP_063671701.1
Location: 1613442..1614485 (1044 bp)
Type: Others
Protein ID: WP_063671703.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ATSB10_RS073201605121..1607541-2421WP_063671699.1TonB-dependent receptor-
ATSB10_RS189151607704..1608066+363WP_083966130.1helix-turn-helix transcriptional regulator-
ATSB10_RS189201608213..1608467+255WP_083966131.1helix-turn-helix domain-containing protein-
ATSB10_RS189251609329..1609607+279WP_083966132.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ATSB10_RS189301609627..1609938+312WP_083966133.1HigA family addiction module antidote proteinAntitoxin
ATSB10_RS193251610658..1611575-918WP_157469154.1hypothetical protein-
ATSB10_RS073251611758..1613440-1683WP_063671701.1DUF262 domain-containing protein-
ATSB10_RS073301613442..1614485-1044WP_063671703.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1583574..162099937425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(30-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10702.13 Da        Isoelectric Point: 6.7014

>T61837 WP_083966132.1 NZ_CP014841:1609329-1609607 [Dyella thiooxydans]
MIHSVSGPLAKELYSGQCPKELELCRTTAERKLTYLDSVVTLEALRYPPGNRLEKLMGNRTGQYSIRINDQYRICFRWEN
DGPHDVEITDYH

Download         Length: 279 bp

>T61837 NZ_CP014841:1609329-1609607 [Dyella thiooxydans]
ATGATCCACTCTGTATCAGGCCCCCTGGCTAAGGAGCTCTATTCCGGGCAGTGTCCTAAGGAACTCGAGCTATGCAGGAC
CACAGCCGAGCGCAAGCTTACCTACCTTGACTCCGTTGTTACGCTCGAAGCGCTTAGGTATCCACCTGGAAATCGACTAG
AAAAATTAATGGGAAATCGGACTGGTCAGTACAGCATCAGGATCAATGATCAGTATCGCATCTGCTTCCGTTGGGAGAAT
GACGGGCCGCATGATGTGGAGATAACCGACTACCATTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11612.43 Da        Isoelectric Point: 7.4046

>AT61837 WP_083966133.1 NZ_CP014841:1609627-1609938 [Dyella thiooxydans]
MVKNGMRAIHPGEILREDFLPGYDMSPNALAQALRVPATRIHAIVNEKRAITADTALRLGRLFATGPDVWMNLQAKFDLR
KAEIEFGEIVEHDVRPIEQRHVG

Download         Length: 312 bp

>AT61837 NZ_CP014841:1609627-1609938 [Dyella thiooxydans]
ATGGTTAAAAATGGCATGCGTGCCATTCATCCAGGGGAGATTCTCAGGGAAGATTTTCTCCCCGGCTATGACATGTCGCC
AAACGCCTTGGCACAGGCTCTTCGTGTTCCGGCGACTCGAATTCACGCGATTGTTAACGAGAAGCGAGCAATCACGGCGG
ATACAGCCCTACGTCTCGGCCGACTGTTCGCAACCGGCCCCGACGTGTGGATGAACTTGCAGGCAAAATTCGATCTACGT
AAAGCGGAAATTGAGTTTGGCGAAATTGTTGAGCATGATGTCCGCCCGATCGAGCAACGACACGTCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References