Detailed information of TA system TA061808

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1922544..1922851
• Replicon: chromosome
• Accession: NZ_CP014791
• Organism: Staphylococcus aureus strain MCRF184

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CKU_RS13635
• Protein ID: WP_011447039.1
• Coordinates: 1922675..1922851 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1922544..1922683 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CKU_RS09500	1917884..1918144	+	261	WP_001791826.1	hypothetical protein	-
CKU_RS09505	1918197..1918547	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CKU_RS09510	1919231..1919680	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CKU_RS13885	1919775..1920110	-	336	Protein_1802	SH3 domain-containing protein	-
CKU_RS09520	1920760..1921251	-	492	WP_000919350.1	staphylokinase	-
CKU_RS09525	1921442..1922197	-	756	WP_000861038.1	CHAP domain-containing protein	-
CKU_RS09530	1922209..1922463	-	255	WP_000611512.1	phage holin	-
CKU_RS09535	1922515..1922622	+	108	WP_001791821.1	hypothetical protein	-
-	1922544..1922683	+	140	NuclAT_0	-	Antitoxin
-	1922544..1922683	+	140	NuclAT_0	-	Antitoxin
-	1922544..1922683	+	140	NuclAT_0	-	Antitoxin
-	1922544..1922683	+	140	NuclAT_0	-	Antitoxin
CKU_RS13635	1922675..1922851	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CKU_RS09540	1923001..1923297	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CKU_RS09545	1923355..1923642	-	288	WP_001040261.1	hypothetical protein	-
CKU_RS09550	1923689..1923841	-	153	WP_001153681.1	hypothetical protein	-
CKU_RS09555	1923831..1927616	-	3786	WP_061869735.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1918197..1953929	35732

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T61808 WP_011447039.1 NZ_CP014791:c1922851-1922675 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T61808 NZ_CP014791:c1922851-1922675 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT61808 NZ_CP014791:1922544-1922683 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin