Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 819725..820326 Replicon chromosome
Accession NZ_CP014671
Organism Immundisolibacter cernigliae strain TR3.2

Toxin (Protein)


Gene name higB Uniprot ID A0A1B1YRJ7
Locus tag PG2T_RS03840 Protein ID WP_068802907.1
Coordinates 820000..820326 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B1YRS4
Locus tag PG2T_RS03835 Protein ID WP_068802906.1
Coordinates 819725..820003 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG2T_RS03815 814975..816876 - 1902 WP_068802903.1 AAA family ATPase -
PG2T_RS15355 816873..817232 - 360 WP_075968131.1 hypothetical protein -
PG2T_RS03820 817232..817450 - 219 WP_145930984.1 hypothetical protein -
PG2T_RS03825 817595..817978 - 384 WP_145930985.1 hypothetical protein -
PG2T_RS03830 818151..819134 + 984 WP_068802296.1 IS5 family transposase -
PG2T_RS03835 819725..820003 - 279 WP_068802906.1 helix-turn-helix domain-containing protein Antitoxin
PG2T_RS03840 820000..820326 - 327 WP_068802907.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PG2T_RS03845 820369..821604 - 1236 WP_068802908.1 integrase arm-type DNA-binding domain-containing protein -
PG2T_RS03860 822008..822577 - 570 WP_202816473.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
PG2T_RS03865 822574..824397 - 1824 WP_068802910.1 excinuclease ABC subunit UvrC -
PG2T_RS03870 824394..825041 - 648 WP_068802911.1 uracil-DNA glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 818151..819134 983


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-82)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12288.40 Da        Isoelectric Point: 10.6449

>T61680 WP_068802907.1 NZ_CP014671:c820326-820000 [Immundisolibacter cernigliae]
MHWTVHALNAEVEAEIKALPADMQARYLRLADLIEAHGLDRIGAPHIKHLEGKLWELRITGRDGIARAIYVTATGRRVVV
LHVFVKKTQKTPPRSLETARKRLKELEP

Download         Length: 327 bp

>T61680 NZ_CP014671:c820326-820000 [Immundisolibacter cernigliae]
ATGCACTGGACAGTCCATGCCCTGAACGCCGAGGTCGAGGCCGAAATCAAGGCCCTGCCCGCCGACATGCAAGCCCGCTA
CCTGCGGCTGGCCGACCTGATCGAGGCCCACGGCCTGGACCGCATCGGGGCACCCCACATCAAACACCTGGAAGGCAAGC
TGTGGGAACTGCGTATCACCGGCCGCGACGGCATCGCCCGTGCGATCTACGTCACAGCTACCGGCCGCCGGGTGGTGGTC
CTGCATGTCTTCGTGAAGAAGACCCAGAAGACCCCGCCGCGTAGCCTGGAAACCGCCAGAAAACGACTGAAGGAACTTGA
GCCATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10114.63 Da        Isoelectric Point: 10.2918

>AT61680 WP_068802906.1 NZ_CP014671:c820003-819725 [Immundisolibacter cernigliae]
MKTHADLKKALLRNPEVRAEYDALEDEFALIAQLIEARARAGLTQAQVAERMGTQQTAVARLEGGRVRPSLATLRRYAEA
TGARIVVRLEAA

Download         Length: 279 bp

>AT61680 NZ_CP014671:c820003-819725 [Immundisolibacter cernigliae]
ATGAAGACCCACGCCGATCTGAAGAAAGCCCTGCTGCGCAACCCGGAAGTCCGGGCCGAGTACGACGCACTGGAAGATGA
ATTCGCGCTGATTGCGCAACTGATCGAGGCCCGCGCCCGTGCCGGCCTGACGCAGGCGCAGGTGGCCGAGCGCATGGGCA
CCCAGCAGACCGCCGTGGCTCGCCTGGAAGGCGGGCGGGTGCGCCCAAGCCTCGCCACCCTGCGTCGCTATGCCGAAGCC
ACCGGCGCGCGCATCGTGGTGCGTCTGGAAGCCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1YRJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1YRS4

References