Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 135506..136077 Replicon chromosome
Accession NZ_CP014671
Organism Immundisolibacter cernigliae strain TR3.2

Toxin (Protein)


Gene name higB Uniprot ID A0A1B1YQ18
Locus tag PG2T_RS00690 Protein ID WP_068802369.1
Coordinates 135506..135784 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A1B1YQ12
Locus tag PG2T_RS00695 Protein ID WP_068802370.1
Coordinates 135784..136077 (+) Length 98 a.a.

Genomic Context

PG2T_RS00665PG2T_RS00670PG2T_RS00675PG2T_RS00680PG2T_RS00690PG2T_RS00695PG2T_RS00700PG2T_RS00705PG2T_RS00710PG2T_RS00685PG2T_RS00715
Location: 130954..131823 (870 bp)
Type: Others
Protein ID: WP_068802365.1
Location: 131857..132321 (465 bp)
Type: Others
Protein ID: WP_068802366.1
Location: 132377..133387 (1011 bp)
Type: Others
Protein ID: WP_068802367.1
Location: 134173..134709 (537 bp)
Type: Others
Protein ID: WP_158513110.1
Location: 135506..135784 (279 bp)
Type: Toxin
Protein ID: WP_068802369.1
Location: 135784..136077 (294 bp)
Type: Antitoxin
Protein ID: WP_068802370.1
Location: 136833..137390 (558 bp)
Type: Others
Protein ID: WP_068802371.1
Location: 137587..138204 (618 bp)
Type: Others
Protein ID: WP_068802372.1
Location: 138343..138954 (612 bp)
Type: Others
Protein ID: WP_068802373.1
Location: 135225..135401 (177 bp)
Type: Others
Protein ID: WP_158513111.1
Location: 138997..140586 (1590 bp)
Type: Others
Protein ID: WP_068802374.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PG2T_RS00665130954..131823+870WP_068802365.1xanthine dehydrogenase family protein subunit M-
PG2T_RS00670131857..132321+465WP_068802366.1SRPBCC family protein-
PG2T_RS00675132377..133387+1011WP_068802367.1ketopantoate reductase family protein-
PG2T_RS00680134173..134709+537WP_158513110.1hypothetical protein-
PG2T_RS00685135225..135401-177WP_158513111.1hypothetical protein-
PG2T_RS00690135506..135784+279WP_068802369.1type II toxin-antitoxin system RelE/ParE family toxinToxin
PG2T_RS00695135784..136077+294WP_068802370.1HigA family addiction module antidote proteinAntitoxin
PG2T_RS00700136833..137390+558WP_068802371.1antibiotic biosynthesis monooxygenase-
PG2T_RS00705137587..138204+618WP_068802372.1class I SAM-dependent methyltransferase-
PG2T_RS00710138343..138954+612WP_068802373.1hypothetical protein-
PG2T_RS00715138997..140586-1590WP_068802374.1AMP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10511.94 Da        Isoelectric Point: 8.5042

>T61678 WP_068802369.1 NZ_CP014671:135506-135784 [Immundisolibacter cernigliae]
MIKSLKHKGLEEFFNSGSTRGIQAAHANKLRMQLAALDTATVIEDMNIPGYRLHPLKGDRKGLWSITVNGNWRVTFEFTD
GNVYIVNYEDYH

Download         Length: 279 bp

>T61678 NZ_CP014671:135506-135784 [Immundisolibacter cernigliae]
ATGATCAAGTCACTCAAGCATAAGGGGCTGGAGGAGTTTTTTAACTCCGGCTCTACTCGCGGTATTCAGGCGGCACATGC
CAATAAACTGCGTATGCAGCTGGCCGCTTTGGATACCGCTACAGTCATAGAAGACATGAACATCCCCGGCTACCGCCTGC
ACCCGCTGAAAGGCGATCGCAAGGGGCTTTGGTCAATTACGGTCAACGGGAACTGGCGCGTCACGTTCGAGTTCACGGAC
GGCAATGTCTATATCGTCAATTACGAGGACTACCACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10720.42 Da        Isoelectric Point: 8.0648

>AT61678 WP_068802370.1 NZ_CP014671:135784-136077 [Immundisolibacter cernigliae]
MAMHNPPHPGEFILATYMEPFGVSCRSLAEHLDVAASTLNRILKQQSGVSPEMALRLSKVLGRSPESWLAMQDAYDLWVA
RKTVKLSGVQRLNLDAA

Download         Length: 294 bp

>AT61678 NZ_CP014671:135784-136077 [Immundisolibacter cernigliae]
ATGGCAATGCACAATCCTCCCCATCCCGGCGAGTTCATCCTGGCGACGTACATGGAGCCTTTTGGGGTCAGCTGCCGGTC
TCTTGCCGAACACCTTGATGTGGCTGCTTCCACCCTTAATCGGATACTGAAGCAGCAGAGTGGTGTTAGCCCGGAAATGG
CGCTGCGTCTCTCGAAGGTGCTCGGCCGCTCCCCTGAGAGCTGGCTTGCCATGCAGGACGCTTATGACCTTTGGGTGGCC
AGGAAAACGGTCAAGCTGTCTGGTGTGCAGCGTCTCAATCTCGATGCCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B1YQ18

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B1YQ12

References