Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3995481..3995703 Replicon chromosome
Accession NZ_CP014667
Organism Escherichia coli strain ECONIH2

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag WM48_RS28765 Protein ID WP_001295224.1
Coordinates 3995481..3995588 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3995637..3995703 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM48_RS19555 3990734..3991486 - 753 WP_000279536.1 cellulose biosynthesis protein BcsQ -
WM48_RS19560 3991498..3991686 - 189 WP_001063314.1 YhjR family protein -
WM48_RS19565 3991959..3993530 + 1572 WP_001204945.1 cellulose biosynthesis protein BcsE -
WM48_RS19570 3993527..3993718 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
WM48_RS19575 3993715..3995394 + 1680 Protein_3747 cellulose biosynthesis protein BcsG -
WM48_RS28765 3995481..3995588 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 3995637..3995703 + 67 - - Antitoxin
WM48_RS19590 3996064..3997335 + 1272 WP_001298005.1 amino acid permease -
WM48_RS19595 3997365..3998369 - 1005 WP_000103577.1 dipeptide ABC transporter ATP-binding subunit DppF -
WM48_RS19600 3998366..3999349 - 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
WM48_RS19605 3999360..4000262 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T61667 WP_001295224.1 NZ_CP014667:c3995588-3995481 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T61667 NZ_CP014667:c3995588-3995481 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT61667 NZ_CP014667:3995637-3995703 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7

Antitoxin

Download structure file

References