Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2404750..2405443 Replicon chromosome
Accession NZ_CP014641
Organism Escherichia coli strain BLK9

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag AYL54_RS12175 Protein ID WP_000415584.1
Coordinates 2405147..2405443 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag AYL54_RS12170 Protein ID WP_000650107.1
Coordinates 2404750..2405145 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYL54_RS12160 (2400614) 2400614..2402872 - 2259 WP_001281877.1 DNA topoisomerase IV subunit A -
AYL54_RS12165 (2403010) 2403010..2404617 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
AYL54_RS12170 (2404750) 2404750..2405145 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
AYL54_RS12175 (2405147) 2405147..2405443 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
AYL54_RS12180 (2405648) 2405648..2406130 - 483 WP_000183505.1 GyrI-like domain-containing protein -
AYL54_RS12185 (2406183) 2406183..2406575 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
AYL54_RS12190 (2406727) 2406727..2407386 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
AYL54_RS12195 (2407383) 2407383..2408732 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
AYL54_RS12200 (2408778) 2408778..2409110 - 333 WP_000917684.1 DUF2645 family protein -
AYL54_RS12205 (2409429) 2409429..2410010 + 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
AYL54_RS12210 (2410041) 2410041..2410355 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T61594 WP_000415584.1 NZ_CP014641:c2405443-2405147 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T61594 NZ_CP014641:c2405443-2405147 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT61594 WP_000650107.1 NZ_CP014641:c2405145-2404750 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT61594 NZ_CP014641:c2405145-2404750 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References