Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1300485..1301212 Replicon chromosome
Accession NZ_CP014608
Organism Obesumbacterium proteus strain DSM 2777

Toxin (Protein)


Gene name higB Uniprot ID A0A806YVR6
Locus tag DSM2777_RS06120 Protein ID WP_061553439.1
Coordinates 1300901..1301212 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A377PPD5
Locus tag DSM2777_RS06115 Protein ID WP_043489166.1
Coordinates 1300485..1300904 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSM2777_RS06095 1295636..1297207 + 1572 WP_061553437.1 crotonobetaine/carnitine-CoA ligase -
DSM2777_RS06100 1297222..1298004 + 783 WP_025798280.1 crotonobetainyl-CoA hydratase -
DSM2777_RS06105 1298689..1299723 + 1035 WP_167669513.1 StbA family protein -
DSM2777_RS06110 1299716..1300399 + 684 WP_061553438.1 hypothetical protein -
DSM2777_RS06115 1300485..1300904 - 420 WP_043489166.1 helix-turn-helix domain-containing protein Antitoxin
DSM2777_RS06120 1300901..1301212 - 312 WP_061553439.1 type II toxin-antitoxin system HigB family toxin Toxin
DSM2777_RS06125 1301567..1302667 + 1101 WP_061553440.1 DUF1615 domain-containing protein -
DSM2777_RS06130 1302803..1303714 + 912 WP_061553441.1 transcriptional regulator FeaR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12449.25 Da        Isoelectric Point: 9.9646

>T61548 WP_061553439.1 NZ_CP014608:c1301212-1300901 [Obesumbacterium proteus]
MHIISRDPFEDAARKYPNDAASLIAAYRLLKENEFGSPTELRKLFPNLDNFKYRNKWWVINIGGNHLRMISYINFVNQRF
YVKHIVTHAEYDKLTRQYREIKE

Download         Length: 312 bp

>T61548 NZ_CP014608:c1301212-1300901 [Obesumbacterium proteus]
ATGCACATCATATCTAGGGATCCGTTTGAAGACGCCGCGCGAAAGTATCCAAACGATGCCGCATCTCTCATCGCAGCATA
TCGATTGCTTAAAGAGAATGAGTTTGGAAGCCCTACGGAATTACGCAAACTGTTCCCTAACCTCGATAATTTCAAATATA
GGAACAAGTGGTGGGTAATCAACATTGGCGGGAACCATCTGCGGATGATTTCCTACATCAACTTTGTAAACCAACGCTTT
TACGTCAAACACATCGTCACCCACGCAGAGTATGACAAGCTAACGAGGCAGTACCGGGAGATAAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15474.70 Da        Isoelectric Point: 4.5542

>AT61548 WP_043489166.1 NZ_CP014608:c1300904-1300485 [Obesumbacterium proteus]
MILEPTKALEAAKVLADAVPFLGGNTSEEAYRDALAMVDYLIEHDDESPLIDFLALKIAEYEDNNERFKAFNQAVTDMPT
GVAALRVLIEQHQLSYSDLASEIGSKSLVSMILSGKRSLTIEHIKALSKRFNVRPDLFF

Download         Length: 420 bp

>AT61548 NZ_CP014608:c1300904-1300485 [Obesumbacterium proteus]
ATGATTTTAGAACCGACCAAAGCGCTAGAGGCCGCAAAAGTATTGGCCGATGCCGTGCCTTTTTTAGGCGGTAATACGTC
TGAGGAGGCCTATCGCGATGCGCTCGCTATGGTTGATTATCTTATCGAGCACGATGACGAAAGCCCGCTAATAGATTTTC
TGGCGTTAAAAATTGCTGAATATGAAGATAACAATGAGCGATTTAAAGCCTTCAATCAGGCCGTGACTGATATGCCTACT
GGCGTGGCTGCGCTACGGGTTCTCATCGAACAACATCAGCTTTCCTACTCAGATTTAGCCTCTGAAATCGGTTCGAAAAG
CCTCGTCAGCATGATTTTATCCGGCAAACGCTCATTAACCATTGAGCATATCAAAGCACTCTCCAAGCGCTTTAACGTTA
GGCCAGACCTGTTTTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806YVR6

Antitoxin

Source ID Structure
AlphaFold DB A0A377PPD5

References