Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 922127..922733 Replicon chromosome
Accession NZ_CP014579
Organism Paraburkholderia phytofirmans OLGA172

Toxin (Protein)


Gene name higB Uniprot ID A0A161I7Q9
Locus tag AYM40_RS24415 Protein ID WP_063498789.1
Coordinates 922401..922733 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3R7IKS7
Locus tag AYM40_RS24410 Protein ID WP_063498788.1
Coordinates 922127..922414 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM40_RS24390 918006..918764 - 759 WP_063498784.1 response regulator transcription factor -
AYM40_RS24395 919105..919296 - 192 WP_063498785.1 hypothetical protein -
AYM40_RS24400 919271..920275 - 1005 WP_063498786.1 cytochrome d ubiquinol oxidase subunit II -
AYM40_RS24405 920299..921711 - 1413 WP_063498787.1 cytochrome ubiquinol oxidase subunit I -
AYM40_RS24410 922127..922414 - 288 WP_063498788.1 helix-turn-helix domain-containing protein Antitoxin
AYM40_RS24415 922401..922733 - 333 WP_063498789.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYM40_RS24420 923225..924037 + 813 WP_063498790.1 NAD(P)-dependent oxidoreductase -
AYM40_RS24425 924067..925359 + 1293 WP_063498791.1 MFS transporter -
AYM40_RS24430 925573..926487 - 915 WP_082855272.1 2-hydroxy-3-oxopropionate reductase -
AYM40_RS24435 926514..927299 - 786 WP_063498793.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12457.59 Da        Isoelectric Point: 10.1358

>T61511 WP_063498789.1 NZ_CP014579:c922733-922401 [Paraburkholderia phytofirmans OLGA172]
MAFTIDFYNEKVKVNVASLPKTLLARFIALADRMEEYGPNLGEPHTASMGGGLFEMRLKGAEGIARVFYCTIVERKIVML
HSFVKKSQQTPRNELDVARKRLLEIRNGNV

Download         Length: 333 bp

>T61511 NZ_CP014579:c922733-922401 [Paraburkholderia phytofirmans OLGA172]
ATGGCATTTACGATCGACTTCTACAACGAAAAGGTCAAAGTGAACGTTGCCTCATTGCCGAAAACGCTGCTCGCGCGCTT
TATCGCGCTGGCCGATCGCATGGAGGAATACGGCCCGAATCTCGGCGAGCCGCACACTGCGTCAATGGGTGGCGGCCTGT
TCGAGATGCGCCTGAAAGGCGCGGAGGGTATCGCCAGAGTGTTCTACTGCACGATCGTGGAACGCAAAATCGTCATGCTT
CACAGTTTCGTGAAGAAGTCACAACAAACGCCGCGTAACGAACTGGACGTGGCGCGCAAAAGACTGCTGGAGATCAGAAA
TGGCAACGTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10594.17 Da        Isoelectric Point: 9.6865

>AT61511 WP_063498788.1 NZ_CP014579:c922414-922127 [Paraburkholderia phytofirmans OLGA172]
MATYKAMRERALADPEVRAEYERLNREEFALLDQMLAARREAGLTQAQVAERMGTKAPAITRLERALASGQHSPSIDTLR
RYAAACGKQLFISIA

Download         Length: 288 bp

>AT61511 NZ_CP014579:c922414-922127 [Paraburkholderia phytofirmans OLGA172]
ATGGCAACGTATAAGGCAATGCGCGAACGGGCGCTCGCCGATCCCGAAGTACGCGCCGAATACGAGCGGCTGAACCGTGA
AGAATTCGCGCTGCTCGATCAGATGCTCGCCGCGCGGCGTGAAGCCGGCTTGACGCAGGCGCAAGTCGCGGAGCGCATGG
GCACGAAAGCGCCCGCTATCACCCGGCTCGAACGGGCGCTTGCTTCGGGGCAGCACTCGCCTTCTATCGACACGTTGCGC
AGATACGCGGCCGCGTGCGGCAAGCAACTGTTTATCTCGATCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A161I7Q9

Antitoxin

Source ID Structure
AlphaFold DB A0A3R7IKS7

References