Detailed information of TA system TA061425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 3239177..3239694
• Replicon: chromosome
• Accession: NZ_CP014545
• Organism: Sphingorhabdus sp. M41

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: AZE99_RS16025
• Protein ID: WP_082788415.1
• Coordinates: 3239177..3239443 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A127MIK3
• Locus tag: AZE99_RS15445
• Protein ID: WP_067202993.1
• Coordinates: 3239440..3239694 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZE99_RS15430	3236154..3237716	+	1563	WP_067202988.1	peptide chain release factor 3	-
AZE99_RS15435	3237734..3239035	+	1302	WP_067202990.1	MFS transporter	-
AZE99_RS16025	3239177..3239443	-	267	WP_082788415.1	Txe/YoeB family addiction module toxin	Toxin
AZE99_RS15445	3239440..3239694	-	255	WP_067202993.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AZE99_RS15450	3239829..3240419	-	591	WP_067202994.1	methionine biosynthesis protein MetW	-
AZE99_RS15455	3240550..3241674	-	1125	WP_067202996.1	homoserine O-acetyltransferase	-
AZE99_RS15460	3241790..3242890	+	1101	WP_067202998.1	histidinol-phosphate transaminase	-
AZE99_RS15465	3242890..3243798	+	909	WP_067202999.1	prephenate/arogenate dehydrogenase family protein	-
AZE99_RS15470	3244060..3244455	-	396	WP_067203001.1	cupin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (5-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10776.32 Da
• Isoelectric Point: 9.9618

>T61425 WP_082788415.1 NZ_CP014545:c3239443-3239177 [Sphingorhabdus sp. M41]
VNVLFSAKSWPEYRYFQEHDPKLSERIYLLIEECRRTPFRGTGKPEPLRGQLKGWWSRRINREHRLVYRVRGEGPEQVLE
IAQCRYHY

Nucleotide

• Length: 267 bp

>T61425 NZ_CP014545:c3239443-3239177 [Sphingorhabdus sp. M41]
GTGAATGTATTATTCTCCGCGAAAAGCTGGCCGGAATATCGATATTTCCAGGAACATGATCCAAAACTTTCCGAACGGAT
ATATTTGCTGATAGAGGAATGTCGCCGAACGCCTTTTCGGGGTACCGGCAAGCCAGAACCATTGCGCGGTCAGCTGAAAG
GCTGGTGGTCGCGGCGCATAAACCGCGAGCATCGCCTAGTCTATCGCGTCCGTGGTGAAGGACCAGAGCAAGTGCTGGAA
ATAGCGCAATGCCGATATCATTATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9530.03 Da
• Isoelectric Point: 5.1667

>AT61425 WP_067202993.1 NZ_CP014545:c3239694-3239440 [Sphingorhabdus sp. M41]
MLMENFSKARANLKALMDRVVADKIPLKITRQNGEAVVMISESEWAGMEETIHLLSSPKNAERLLESIRQLDAGEGFEPE
LFKR

Nucleotide

• Length: 255 bp

>AT61425 NZ_CP014545:c3239694-3239440 [Sphingorhabdus sp. M41]
ATGCTGATGGAAAATTTCTCGAAGGCCCGCGCCAATCTCAAGGCGCTGATGGACCGCGTTGTGGCCGACAAGATTCCCCT
GAAAATCACTCGCCAGAATGGCGAGGCGGTGGTCATGATCTCCGAGAGTGAGTGGGCCGGTATGGAAGAAACTATTCATT
TGTTGTCTTCACCAAAAAATGCGGAGCGCCTGCTGGAGTCGATTAGGCAACTTGATGCCGGAGAGGGATTCGAGCCTGAG
CTTTTCAAGCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A127MIK3