Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1084448..1085043 Replicon chromosome
Accession NZ_CP014539
Organism Acinetobacter baumannii strain XH859

Toxin (Protein)


Gene name higB Uniprot ID A0A7M3FN97
Locus tag AYR68_RS05265 Protein ID WP_032053387.1
Coordinates 1084762..1085043 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A7M3FNJ1
Locus tag AYR68_RS05260 Protein ID WP_032053385.1
Coordinates 1084448..1084732 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR68_RS19690 1079586..1079756 + 171 WP_162921993.1 hypothetical protein -
AYR68_RS05220 1079769..1080176 + 408 WP_038338740.1 hypothetical protein -
AYR68_RS05225 1080148..1080516 + 369 WP_020752396.1 hypothetical protein -
AYR68_RS05230 1080473..1080916 + 444 WP_073545229.1 hypothetical protein -
AYR68_RS05235 1080918..1081136 + 219 WP_020752398.1 hypothetical protein -
AYR68_RS05240 1081232..1081582 + 351 WP_020752399.1 hypothetical protein -
AYR68_RS05245 1081582..1082565 + 984 WP_020752400.1 hypothetical protein -
AYR68_RS05250 1082660..1083577 + 918 WP_020752401.1 hypothetical protein -
AYR68_RS05255 1083648..1084157 + 510 WP_038338755.1 hypothetical protein -
AYR68_RS05260 1084448..1084732 - 285 WP_032053385.1 HigA family addiction module antidote protein Antitoxin
AYR68_RS05265 1084762..1085043 - 282 WP_032053387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYR68_RS05270 1085198..1085542 + 345 WP_038338750.1 hypothetical protein -
AYR68_RS05275 1085665..1086174 + 510 WP_038338751.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage blaOXA-23 - 1033409..1098256 64847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10651.02 Da        Isoelectric Point: 8.5123

>T61412 WP_032053387.1 NZ_CP014539:c1085043-1084762 [Acinetobacter baumannii]
MIKSFKHKGLQAFFEEGSTAGIQAAHSKKLRLLLASLNAATSVYDLRTPPNWRLHELKGNLEGHWSLTVNGNWRVTFKFE
DGDAYIVDYQDYH

Download         Length: 282 bp

>T61412 NZ_CP014539:c1085043-1084762 [Acinetobacter baumannii]
TTGATTAAGAGTTTCAAGCATAAGGGGTTGCAAGCTTTCTTTGAAGAAGGCTCAACTGCTGGTATCCAAGCTGCTCACTC
TAAGAAATTACGTTTACTTTTAGCTTCATTGAATGCTGCCACCTCAGTTTATGACTTGAGGACACCACCAAATTGGCGCT
TACATGAATTAAAAGGCAATCTTGAAGGTCATTGGTCTTTAACTGTAAACGGAAATTGGCGTGTAACGTTTAAATTTGAA
GATGGCGATGCATACATCGTGGATTATCAAGATTATCACTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10330.89 Da        Isoelectric Point: 7.3174

>AT61412 WP_032053385.1 NZ_CP014539:c1084732-1084448 [Acinetobacter baumannii]
MKVMFNAPHPGEILQEYLEGISVTSAARALGVTRANLSRILNGHTGISADMALRLSEALSTSPEFWLNLQVQYDLWIASQ
NKRPTIQHLAPAMA

Download         Length: 285 bp

>AT61412 NZ_CP014539:c1084732-1084448 [Acinetobacter baumannii]
ATGAAAGTTATGTTTAATGCACCACACCCTGGCGAAATTCTTCAAGAGTATCTAGAGGGCATTTCAGTTACTAGCGCAGC
ACGAGCATTGGGCGTTACTCGTGCAAACTTATCTCGCATCCTCAATGGCCATACTGGTATATCAGCTGATATGGCGCTTC
GTCTTTCTGAAGCCCTTAGCACCTCACCAGAATTCTGGTTAAACTTGCAAGTACAGTATGATCTTTGGATTGCCAGCCAA
AATAAGCGGCCAACGATTCAGCATTTAGCGCCAGCAATGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M3FN97

Antitoxin

Source ID Structure
AlphaFold DB A0A7M3FNJ1

References