Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 5048..5580 Replicon plasmid unnamed 2
Accession NZ_CP014527
Organism Haematospirillum jordaniae strain H5569

Toxin (Protein)


Gene name yafQ Uniprot ID A0A143DG99
Locus tag AY555_RS10235 Protein ID WP_066137009.1
Coordinates 5048..5320 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A143DH71
Locus tag AY555_RS10240 Protein ID WP_066137371.1
Coordinates 5320..5580 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AY555_RS10210 644..1846 + 1203 WP_066133065.1 transposase -
AY555_RS10215 1903..2583 - 681 WP_167798514.1 hypothetical protein -
AY555_RS10220 2928..3204 - 277 Protein_3 single-stranded DNA-binding protein -
AY555_RS10225 3616..4626 + 1011 WP_066137004.1 calcium-binding protein -
AY555_RS10230 4623..4877 - 255 WP_066137006.1 phage major tail tube protein -
AY555_RS10235 5048..5320 - 273 WP_066137009.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
AY555_RS10240 5320..5580 - 261 WP_066137371.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AY555_RS10245 5805..6446 + 642 WP_066137011.1 AAA family ATPase -
AY555_RS10250 6486..6752 + 267 WP_066137013.1 ribbon-helix-helix domain-containing protein -
AY555_RS10255 6870..8576 - 1707 WP_066137015.1 recombinase family protein -
AY555_RS10260 8656..8991 - 336 WP_066137017.1 hypothetical protein -
AY555_RS10265 9625..10008 + 384 WP_066137018.1 MbcA/ParS/Xre antitoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ugd 1..303116 303116


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-84)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10568.13 Da        Isoelectric Point: 10.2626

>T61402 WP_066137009.1 NZ_CP014527:c5320-5048 [Haematospirillum jordaniae]
MRHPEYSGQFKRDVKASGRRGKDMSKLKVLIELLIAGTPLPATYLDHPLKGRWRSYRDAHIESDWLLIYKINGNVVRFER
TGRHTDLFDE

Download         Length: 273 bp

>T61402 NZ_CP014527:c5320-5048 [Haematospirillum jordaniae]
ATGCGGCACCCGGAGTATTCTGGCCAGTTCAAGCGTGACGTCAAGGCTTCTGGAAGGCGTGGCAAGGACATGAGCAAGCT
CAAGGTTCTGATAGAGCTGCTGATAGCAGGTACGCCGTTGCCTGCCACGTATCTCGACCACCCGCTTAAAGGGCGGTGGC
GTAGCTACCGGGATGCCCACATTGAGTCGGACTGGCTTCTGATCTACAAAATCAATGGCAATGTTGTCCGCTTTGAACGA
ACTGGACGGCACACCGATCTTTTCGACGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9257.61 Da        Isoelectric Point: 5.5882

>AT61402 WP_066137371.1 NZ_CP014527:c5580-5320 [Haematospirillum jordaniae]
MKANAFVRARIDETLKNEAAAVLAGMGLTVSDVVRIALTKIAKEKTLPFDMRVPNALTAETLAKSEHGEDVHHANDADDL
FAQLGI

Download         Length: 261 bp

>AT61402 NZ_CP014527:c5580-5320 [Haematospirillum jordaniae]
ATGAAAGCAAATGCATTTGTCCGCGCCCGGATCGACGAGACGCTAAAAAACGAAGCCGCTGCCGTACTGGCGGGTATGGG
GCTTACTGTGTCCGATGTAGTGCGCATTGCCCTCACCAAAATCGCCAAAGAAAAGACGCTGCCATTCGACATGCGCGTTC
CTAACGCACTGACGGCGGAAACGCTGGCGAAAAGTGAGCATGGTGAAGATGTTCACCATGCCAACGATGCGGATGATCTG
TTTGCCCAGCTGGGTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143DG99

Antitoxin

Source ID Structure
AlphaFold DB A0A143DH71

References