Detailed information of TA system TA061363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1136650..1137255
• Replicon: chromosome
• Accession: NZ_CP014505
• Organism: Burkholderia sp. PAMC 28687

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AX768_RS05205
• Protein ID: WP_075360460.1
• Coordinates: 1136968..1137255 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AX768_RS05200
• Protein ID: WP_061999063.1
• Coordinates: 1136650..1136952 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AX768_RS05190	1133765..1135471	-	1707	WP_061999061.1	single-stranded-DNA-specific exonuclease RecJ	-
AX768_RS05195	1135484..1136605	-	1122	WP_061999062.1	hypothetical protein	-
AX768_RS05200	1136650..1136952	-	303	WP_061999063.1	HigA family addiction module antidote protein	Antitoxin
AX768_RS05205	1136968..1137255	-	288	WP_075360460.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AX768_RS05210	1137645..1138898	+	1254	WP_061999064.1	lipoprotein-releasing ABC transporter permease subunit	-
AX768_RS05215	1138891..1139598	+	708	WP_061999065.1	lipoprotein-releasing ABC transporter ATP-binding protein LolD	-
AX768_RS05220	1139621..1140409	+	789	WP_061999066.1	TatD family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (8-95)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-81)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10947.53 Da
• Isoelectric Point: 9.7808

>T61363 WP_075360460.1 NZ_CP014505:c1137255-1136968 [Burkholderia sp. PAMC 28687]
MTIMIQTFRCKDTQALYEGETPKRFAAIADVATRRLSALDASHELRDLKSPPGNRLERLSGDRRGQLSIRINSQWRVCFK
WTTKGPVDVEIIDYH

Nucleotide

• Length: 288 bp

>T61363 NZ_CP014505:c1137255-1136968 [Burkholderia sp. PAMC 28687]
ATGACCATAATGATTCAAACGTTCCGATGCAAGGACACCCAGGCACTTTACGAAGGTGAAACGCCGAAGCGGTTCGCAGC
AATTGCAGATGTCGCGACCAGAAGGCTTTCGGCGCTGGATGCTTCGCACGAGTTGCGCGACCTGAAATCACCGCCCGGCA
ACCGTCTCGAACGGCTGTCGGGCGACCGGCGGGGCCAGCTCAGCATTCGGATCAACAGCCAGTGGCGCGTTTGTTTCAAA
TGGACGACGAAGGGTCCTGTCGACGTCGAGATCATTGACTATCACTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11522.27 Da
• Isoelectric Point: 8.4844

>AT61363 WP_061999063.1 NZ_CP014505:c1136952-1136650 [Burkholderia sp. PAMC 28687]
MSKNGMRAVHPGEILREDYLVPLELSVNALALALNVPATRLHEIVKERRGITADTAYRLARYFDTTPEFWLNLQAMYDLK
TLPTRSEIDRKVEPREPTRA

Nucleotide

• Length: 303 bp

>AT61363 NZ_CP014505:c1136952-1136650 [Burkholderia sp. PAMC 28687]
ATGTCGAAGAACGGAATGCGCGCAGTTCATCCCGGAGAAATTCTCCGGGAAGACTATCTGGTTCCGCTGGAGTTGAGCGT
CAACGCGCTGGCGCTGGCGCTCAACGTGCCGGCCACGCGGCTGCACGAGATCGTGAAGGAACGGCGCGGCATCACGGCGG
ATACGGCTTATCGCCTCGCGCGCTACTTCGACACCACGCCTGAATTCTGGTTGAATCTGCAGGCCATGTACGACCTCAAG
ACACTGCCCACACGCAGTGAAATCGATCGAAAAGTCGAACCGCGCGAGCCTACCCGCGCTTAA