Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3107723..3108399 Replicon chromosome
Accession NZ_CP014485
Organism Streptomyces albidoflavus strain SM254

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag Salbus254_RS13325 Protein ID WP_018471256.1
Coordinates 3108037..3108399 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Salbus254_RS13320 Protein ID WP_018471255.1
Coordinates 3107723..3108040 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Salbus254_RS13295 3103009..3104070 + 1062 WP_030308230.1 hypothetical protein -
Salbus254_RS13300 3104286..3104816 + 531 WP_003949893.1 toxin-antitoxin system HicB family antitoxin -
Salbus254_RS13305 3104918..3105787 + 870 WP_061404478.1 DUF4097 family beta strand repeat protein -
Salbus254_RS13310 3105891..3106865 + 975 Protein_2633 ATP-binding cassette domain-containing protein -
Salbus254_RS13315 3106862..3107644 + 783 WP_003949890.1 ABC transporter permease -
Salbus254_RS13320 3107723..3108040 - 318 WP_018471255.1 helix-turn-helix domain-containing protein Antitoxin
Salbus254_RS13325 3108037..3108399 - 363 WP_018471256.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Salbus254_RS13330 3108398..3110095 + 1698 WP_061404479.1 hypothetical protein -
Salbus254_RS13335 3110185..3110427 - 243 WP_015507388.1 hypothetical protein -
Salbus254_RS13340 3110731..3111585 + 855 WP_030308234.1 STAS domain-containing protein -
Salbus254_RS13345 3111582..3111962 + 381 WP_003949885.1 STAS domain-containing protein -
Salbus254_RS13350 3111962..3112378 + 417 WP_003949884.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13502.36 Da        Isoelectric Point: 4.6168

>T61261 WP_018471256.1 NZ_CP014485:c3108399-3108037 [Streptomyces albidoflavus]
MDGEWQIFLVDEVRVWLASLDGAAHARVVQALDVLAEEGPALGRPLVDTLRGSAVANLKELRPGTVRILFAFDPWRSSIL
LVAGDKSGQWTEWYQEAIPLAEQRYALYLKEREREEGGRP

Download         Length: 363 bp

>T61261 NZ_CP014485:c3108399-3108037 [Streptomyces albidoflavus]
ATGGACGGGGAATGGCAGATCTTCCTGGTTGACGAGGTGCGTGTTTGGCTCGCGTCCCTCGACGGGGCCGCGCACGCACG
AGTGGTGCAGGCGCTGGACGTGCTGGCCGAGGAAGGGCCTGCTCTCGGAAGACCGCTTGTGGACACCTTGCGTGGTTCAG
CGGTGGCCAATTTGAAAGAGCTCCGGCCCGGCACGGTCAGAATTCTGTTCGCCTTCGATCCGTGGCGTTCCAGCATCTTG
CTGGTGGCAGGTGACAAGTCCGGGCAGTGGACTGAGTGGTACCAGGAGGCGATCCCCCTGGCCGAGCAGCGCTACGCGCT
TTACTTGAAGGAACGTGAGCGGGAAGAGGGAGGACGACCATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11558.05 Da        Isoelectric Point: 9.8236

>AT61261 WP_018471255.1 NZ_CP014485:c3108040-3107723 [Streptomyces albidoflavus]
MTSYTRWQDIRPEHVARAGGEEAVRAGKEELLAQVTGRKLAELRRARGLTQQEVADRMGVSKGRVSQIERGHLSGQEVLA
RFATALGGRLHQAIYFDDGDIATIA

Download         Length: 318 bp

>AT61261 NZ_CP014485:c3108040-3107723 [Streptomyces albidoflavus]
ATGACGAGTTACACCCGTTGGCAGGACATTCGTCCCGAGCATGTCGCCCGCGCAGGGGGTGAGGAAGCCGTACGCGCGGG
TAAGGAGGAGCTGCTCGCGCAGGTCACCGGGAGGAAGCTCGCGGAGCTGCGTCGCGCCCGAGGGCTGACCCAGCAGGAGG
TGGCGGACCGGATGGGGGTCAGCAAGGGGCGGGTCTCCCAGATCGAGCGGGGGCACCTTTCGGGACAGGAAGTGCTGGCC
CGATTCGCGACCGCTCTCGGAGGCCGTCTCCATCAGGCGATCTACTTCGACGACGGCGACATCGCCACCATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References