61227

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2577218..2577735 Replicon chromosome
Accession NZ_CP014444
Organism Staphylococcus aureus strain USA300-SUR24

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag AYM37_RS13705 Protein ID WP_000113262.1
Coordinates 2577218..2577484 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag AYM37_RS13710 Protein ID WP_000584502.1
Coordinates 2577484..2577735 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM37_RS13680 2572644..2573180 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
AYM37_RS13685 2573413..2574237 - 825 WP_000572040.1 formate/nitrite transporter family protein -
AYM37_RS13690 2574454..2574636 - 183 WP_000230294.1 hypothetical protein -
AYM37_RS13695 2574720..2575187 - 468 WP_000153344.1 SRPBCC domain-containing protein -
AYM37_RS13700 2575373..2576923 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
AYM37_RS16005 2577112..2577183 - 72 Protein_2536 hypothetical protein -
AYM37_RS13705 2577218..2577484 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
AYM37_RS13710 2577484..2577735 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AYM37_RS13715 2577900..2578001 - 102 WP_001791744.1 hypothetical protein -
AYM37_RS13720 2578008..2578607 - 600 WP_000162813.1 DsbA family protein -
AYM37_RS13725 2578626..2578985 - 360 WP_000819847.1 DUF4467 domain-containing protein -
AYM37_RS13730 2579240..2580490 + 1251 Protein_2542 FemA/FemB family glycyltransferase FmhA -
AYM37_RS13735 2580587..2581318 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
AYM37_RS13740 2581315..2582034 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T61227 WP_000113262.1 NZ_CP014444:c2577484-2577218 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T61227 NZ_CP014444:c2577484-2577218 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT61227 WP_000584502.1 NZ_CP014444:c2577735-2577484 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT61227 NZ_CP014444:c2577735-2577484 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References