Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2312464..2312727 Replicon chromosome
Accession NZ_CP014444
Organism Staphylococcus aureus strain USA300-SUR24

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag AYM37_RS12290 Protein ID WP_001802298.1
Coordinates 2312623..2312727 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2312464..2312628 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM37_RS12270 2308647..2309312 - 666 WP_001024094.1 SDR family oxidoreductase -
AYM37_RS12275 2309464..2309784 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
AYM37_RS12280 2309786..2310766 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
AYM37_RS12285 2311032..2312123 + 1092 WP_000495671.1 lytic regulatory protein -
- 2312464..2312628 + 165 - - Antitoxin
AYM37_RS12290 2312623..2312727 - 105 WP_001802298.1 hypothetical protein Toxin
AYM37_RS15995 2312888..2313371 - 484 Protein_2270 recombinase family protein -
AYM37_RS12300 2313414..2314550 - 1137 WP_000115564.1 SAP domain-containing protein -
AYM37_RS12305 2314839..2314931 + 93 WP_001790138.1 hypothetical protein -
AYM37_RS12310 2315636..2316493 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
AYM37_RS12315 2316561..2317343 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T61225 WP_001802298.1 NZ_CP014444:c2312727-2312623 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T61225 NZ_CP014444:c2312727-2312623 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT61225 NZ_CP014444:2312464-2312628 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References