Detailed information of TA system TA061217

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2137669..2137968
• Replicon: chromosome
• Accession: NZ_CP014444
• Organism: Staphylococcus aureus strain USA300-SUR24

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AYM37_RS11250
• Protein ID: WP_011447039.1
• Coordinates: 2137792..2137968 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2137669..2137724 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM37_RS11195	2133001..2133261	+	261	WP_001791826.1	hypothetical protein	-
AYM37_RS11200	2133314..2133664	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AYM37_RS11205	2134349..2134798	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AYM37_RS15990	2134893..2135228	-	336	Protein_2072	SH3 domain-containing protein	-
AYM37_RS11230	2135878..2136368	-	491	Protein_2073	staphylokinase	-
AYM37_RS11235	2136559..2137314	-	756	WP_000861038.1	CHAP domain-containing protein	-
AYM37_RS11240	2137326..2137580	-	255	WP_000611512.1	phage holin	-
AYM37_RS11245	2137632..2137739	+	108	WP_001791821.1	hypothetical protein	-
-	2137661..2137800	+	140	NuclAT_0	-	-
-	2137661..2137800	+	140	NuclAT_0	-	-
-	2137661..2137800	+	140	NuclAT_0	-	-
-	2137661..2137800	+	140	NuclAT_0	-	-
-	2137669..2137724	+	56	-	-	Antitoxin
AYM37_RS11250	2137792..2137968	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AYM37_RS11255	2138118..2138414	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AYM37_RS11260	2138472..2138759	-	288	WP_001040261.1	hypothetical protein	-
AYM37_RS11265	2138806..2138958	-	153	WP_001153681.1	hypothetical protein	-
AYM37_RS11270	2138948..2142733	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2133314..2189261	55947

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T61217 WP_011447039.1 NZ_CP014444:c2137968-2137792 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T61217 NZ_CP014444:c2137968-2137792 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT61217 NZ_CP014444:2137669-2137724 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin