Detailed information of TA system TA061208

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2308049..2308266
• Replicon: chromosome
• Accession: NZ_CP014441
• Organism: Staphylococcus aureus strain USA300-SUR23

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: AYM36_RS12255
• Protein ID: WP_001802298.1
• Coordinates: 2308162..2308266 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2308049..2308104 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM36_RS12235	2304186..2304851	-	666	WP_001024094.1	SDR family oxidoreductase	-
AYM36_RS12240	2305003..2305323	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
AYM36_RS12245	2305325..2306305	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
AYM36_RS12250	2306571..2307662	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2308049..2308104	+	56	-	-	Antitoxin
AYM36_RS12255	2308162..2308266	-	105	WP_001802298.1	hypothetical protein	Toxin
AYM36_RS15755	2308427..2308910	-	484	Protein_2264	recombinase family protein	-
AYM36_RS12265	2308953..2310089	-	1137	WP_000115564.1	SAP domain-containing protein	-
AYM36_RS12270	2310378..2310470	+	93	WP_001790138.1	hypothetical protein	-
AYM36_RS12275	2311175..2312032	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
AYM36_RS12280	2312100..2312882	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T61208 WP_001802298.1 NZ_CP014441:c2308266-2308162 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T61208 NZ_CP014441:c2308266-2308162 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT61208 NZ_CP014441:2308049-2308104 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin