61191

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2572748..2573265 Replicon chromosome
Accession NZ_CP014438
Organism Staphylococcus aureus strain USA300-SUR22

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag AYM35_RS13670 Protein ID WP_000113262.1
Coordinates 2572748..2573014 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag AYM35_RS13675 Protein ID WP_000584502.1
Coordinates 2573014..2573265 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM35_RS13645 2568174..2568710 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
AYM35_RS13650 2568943..2569767 - 825 WP_000572040.1 formate/nitrite transporter family protein -
AYM35_RS13655 2569984..2570166 - 183 WP_000230294.1 hypothetical protein -
AYM35_RS13660 2570250..2570717 - 468 WP_000153344.1 SRPBCC domain-containing protein -
AYM35_RS13665 2570903..2572453 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
AYM35_RS15765 2572642..2572713 - 72 Protein_2530 hypothetical protein -
AYM35_RS13670 2572748..2573014 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
AYM35_RS13675 2573014..2573265 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AYM35_RS13680 2573430..2573531 - 102 WP_001791744.1 hypothetical protein -
AYM35_RS13685 2573538..2574137 - 600 WP_077445428.1 DsbA family protein -
AYM35_RS13690 2574156..2574515 - 360 WP_000819847.1 DUF4467 domain-containing protein -
AYM35_RS13695 2574770..2576020 + 1251 Protein_2536 FemA/FemB family glycyltransferase FmhA -
AYM35_RS13700 2576117..2576848 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
AYM35_RS13705 2576845..2577564 - 720 WP_077445430.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T61191 WP_000113262.1 NZ_CP014438:c2573014-2572748 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T61191 NZ_CP014438:c2573014-2572748 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT61191 WP_000584502.1 NZ_CP014438:c2573265-2573014 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT61191 NZ_CP014438:c2573265-2573014 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References