Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelE |
| Location | 29150..29673 | Replicon | metagenomic gene cluster |
| Accession | KF033132 | ||
| Organism | uncultured bacterium clone 93 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | Locus_27 | Protein ID | AGT60063.1 |
| Coordinates | 29150..29443 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | Locus_28 | Protein ID | AGT60064.1 |
| Coordinates | 29434..29673 (-) | Length | 80 a.a. |
Genomic Context
Location: 33370..34317 (948 bp)
Type: Others
Protein ID: AGT60069.1
Type: Others
Protein ID: AGT60069.1
Location: 24191..25258 (1068 bp)
Type: Others
Protein ID: AGT60057.1
Type: Others
Protein ID: AGT60057.1
Location: 25285..25926 (642 bp)
Type: Others
Protein ID: AGT60058.1
Type: Others
Protein ID: AGT60058.1
Location: 26066..26176 (111 bp)
Type: Others
Protein ID: AGT60059.1
Type: Others
Protein ID: AGT60059.1
Location: 26189..26875 (687 bp)
Type: Others
Protein ID: AGT60060.1
Type: Others
Protein ID: AGT60060.1
Location: 26880..27686 (807 bp)
Type: Others
Protein ID: AGT60061.1
Type: Others
Protein ID: AGT60061.1
Location: 27701..29062 (1362 bp)
Type: Others
Protein ID: AGT60062.1
Type: Others
Protein ID: AGT60062.1
Location: 29150..29443 (294 bp)
Type: Toxin
Protein ID: AGT60063.1
Type: Toxin
Protein ID: AGT60063.1
Location: 29434..29673 (240 bp)
Type: Antitoxin
Protein ID: AGT60064.1
Type: Antitoxin
Protein ID: AGT60064.1
Location: 29837..30721 (885 bp)
Type: Others
Protein ID: AGT60065.1
Type: Others
Protein ID: AGT60065.1
Location: 30759..31544 (786 bp)
Type: Others
Protein ID: AGT60066.1
Type: Others
Protein ID: AGT60066.1
Location: 31563..32192 (630 bp)
Type: Others
Protein ID: AGT60067.1
Type: Others
Protein ID: AGT60067.1
Location: 32262..33029 (768 bp)
Type: Others
Protein ID: AGT60068.1
Type: Others
Protein ID: AGT60068.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Locus_21 | 24191..25258 | - | 1068 | AGT60057.1 | ribosome-associated GTPase | - |
| Locus_22 | 25285..25926 | - | 642 | AGT60058.1 | hypothetical protein | - |
| Locus_23 | 26066..26176 | - | 111 | AGT60059.1 | hypothetical protein | - |
| Locus_24 | 26189..26875 | - | 687 | AGT60060.1 | Fic/Doc protein | - |
| Locus_25 | 26880..27686 | - | 807 | AGT60061.1 | hypothetical protein | - |
| Locus_26 | 27701..29062 | - | 1362 | AGT60062.1 | hypothetical protein | - |
| Locus_27 | 29150..29443 | - | 294 | AGT60063.1 | RelE/StbE | Toxin |
| Locus_28 | 29434..29673 | - | 240 | AGT60064.1 | CopG | Antitoxin |
| Locus_29 | 29837..30721 | - | 885 | AGT60065.1 | HisG | - |
| Locus_30 | 30759..31544 | - | 786 | AGT60066.1 | HisB | - |
| Locus_31 | 31563..32192 | - | 630 | AGT60067.1 | HisI | - |
| Locus_32 | 32262..33029 | - | 768 | AGT60068.1 | HisF | - |
| Locus_33 | 33370..34317 | + | 948 | AGT60069.1 | TehA | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11411.55 Da Isoelectric Point: 10.2958
>T6114 AGT60063.1 KF033132:c29443-29150 [uncultured bacterium]
MALNILWTKRVLANLESELDYYGQINLLLAKELTLIIRQSIDTIYRMPAIGRAGKKIGTRELVIEKYPYILAYRVRNDVL
EILAIIHQKRKNIRSHY
MALNILWTKRVLANLESELDYYGQINLLLAKELTLIIRQSIDTIYRMPAIGRAGKKIGTRELVIEKYPYILAYRVRNDVL
EILAIIHQKRKNIRSHY
Download Length: 294 bp
>T6114 KF033132:c29443-29150 [uncultured bacterium]
ATGGCTCTAAATATCCTGTGGACGAAACGCGTACTAGCCAACTTAGAGTCTGAGCTTGATTACTATGGACAAATTAATCT
ACTCTTGGCAAAAGAACTAACTTTAATCATTCGACAATCTATCGACACTATTTATCGTATGCCAGCCATTGGACGCGCAG
GTAAGAAGATTGGCACTCGGGAGTTAGTCATTGAAAAATACCCATATATTTTGGCATATCGCGTGAGAAATGATGTTCTT
GAAATTTTGGCAATAATTCATCAAAAGCGCAAGAATATCCGCAGTCATTATTGA
ATGGCTCTAAATATCCTGTGGACGAAACGCGTACTAGCCAACTTAGAGTCTGAGCTTGATTACTATGGACAAATTAATCT
ACTCTTGGCAAAAGAACTAACTTTAATCATTCGACAATCTATCGACACTATTTATCGTATGCCAGCCATTGGACGCGCAG
GTAAGAAGATTGGCACTCGGGAGTTAGTCATTGAAAAATACCCATATATTTTGGCATATCGCGTGAGAAATGATGTTCTT
GAAATTTTGGCAATAATTCATCAAAAGCGCAAGAATATCCGCAGTCATTATTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9103.42 Da Isoelectric Point: 4.5173
>AT6114 AGT60064.1 KF033132:c29673-29434 [uncultured bacterium]
MKTENPVISFRVPSEIYDKLEQLVKATKRNKADLLLHWLEEAISLEEWQLQEVEAGIKEADAGMFASSAETERVLTKWL
MKTENPVISFRVPSEIYDKLEQLVKATKRNKADLLLHWLEEAISLEEWQLQEVEAGIKEADAGMFASSAETERVLTKWL
Download Length: 240 bp
>AT6114 KF033132:c29673-29434 [uncultured bacterium]
ATGAAAACAGAAAACCCCGTAATTTCATTTCGCGTACCAAGTGAAATATATGATAAGCTCGAACAACTAGTTAAAGCGAC
TAAGCGCAACAAGGCTGATTTGTTATTACATTGGCTAGAAGAAGCAATATCCCTCGAAGAGTGGCAACTACAGGAAGTTG
AAGCCGGAATTAAAGAAGCCGACGCAGGTATGTTTGCATCATCCGCAGAAACAGAGCGAGTTTTAACCAAATGGCTCTAA
ATGAAAACAGAAAACCCCGTAATTTCATTTCGCGTACCAAGTGAAATATATGATAAGCTCGAACAACTAGTTAAAGCGAC
TAAGCGCAACAAGGCTGATTTGTTATTACATTGGCTAGAAGAAGCAATATCCCTCGAAGAGTGGCAACTACAGGAAGTTG
AAGCCGGAATTAAAGAAGCCGACGCAGGTATGTTTGCATCATCCGCAGAAACAGAGCGAGTTTTAACCAAATGGCTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10119 | Escherichia coli | 31.868 | 98.913 | 0.315 |
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Multiple sequence alignment
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| No matching records found | ||||
References
(1) Ken Vercammen et al. (2013) Identification of a metagenomic gene cluster containing a new class A beta-lactamase and toxin-antitoxin systems. MicrobiologyOpen 2(4):674-83. [PubMed:23873667]