Detailed information of TA system TA061109

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2137660..2137959
• Replicon: chromosome
• Accession: NZ_CP014426
• Organism: Staphylococcus aureus strain USA300-SUR18

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AYM31_RS11250
• Protein ID: WP_011447039.1
• Coordinates: 2137783..2137959 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2137660..2137715 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM31_RS11195	2132991..2133251	+	261	WP_001791826.1	hypothetical protein	-
AYM31_RS11200	2133304..2133654	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AYM31_RS11205	2134339..2134788	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AYM31_RS15785	2134883..2135218	-	336	Protein_2072	SH3 domain-containing protein	-
AYM31_RS11230	2135868..2136359	-	492	WP_000919350.1	staphylokinase	-
AYM31_RS11235	2136550..2137305	-	756	WP_000861038.1	CHAP domain-containing protein	-
AYM31_RS11240	2137317..2137571	-	255	WP_000611512.1	phage holin	-
AYM31_RS11245	2137623..2137730	+	108	WP_001791821.1	hypothetical protein	-
-	2137652..2137791	+	140	NuclAT_0	-	-
-	2137652..2137791	+	140	NuclAT_0	-	-
-	2137652..2137791	+	140	NuclAT_0	-	-
-	2137652..2137791	+	140	NuclAT_0	-	-
-	2137660..2137715	+	56	-	-	Antitoxin
AYM31_RS11250	2137783..2137959	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AYM31_RS11255	2138109..2138405	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AYM31_RS11260	2138463..2138750	-	288	WP_001040261.1	hypothetical protein	-
AYM31_RS11265	2138797..2138949	-	153	WP_001153681.1	hypothetical protein	-
AYM31_RS11270	2138939..2142724	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2133304..2189252	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T61109 WP_011447039.1 NZ_CP014426:c2137959-2137783 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T61109 NZ_CP014426:c2137959-2137783 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT61109 NZ_CP014426:2137660-2137715 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin