Detailed information of TA system TA061019

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2137490..2137789
• Replicon: chromosome
• Accession: NZ_CP014409
• Organism: Staphylococcus aureus strain USA300-SUR13

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AYM26_RS11230
• Protein ID: WP_011447039.1
• Coordinates: 2137613..2137789 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2137490..2137545 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM26_RS11175	2132821..2133081	+	261	WP_001791826.1	hypothetical protein	-
AYM26_RS11180	2133134..2133484	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AYM26_RS11185	2134169..2134618	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AYM26_RS15785	2134713..2135048	-	336	Protein_2073	SH3 domain-containing protein	-
AYM26_RS11210	2135698..2136189	-	492	WP_000919350.1	staphylokinase	-
AYM26_RS11215	2136380..2137135	-	756	WP_000861038.1	CHAP domain-containing protein	-
AYM26_RS11220	2137147..2137401	-	255	WP_000611512.1	phage holin	-
AYM26_RS11225	2137453..2137560	+	108	WP_001791821.1	hypothetical protein	-
-	2137482..2137621	+	140	NuclAT_0	-	-
-	2137482..2137621	+	140	NuclAT_0	-	-
-	2137482..2137621	+	140	NuclAT_0	-	-
-	2137482..2137621	+	140	NuclAT_0	-	-
-	2137490..2137545	+	56	-	-	Antitoxin
AYM26_RS11230	2137613..2137789	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AYM26_RS11235	2137939..2138235	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AYM26_RS11240	2138293..2138580	-	288	WP_001040261.1	hypothetical protein	-
AYM26_RS11245	2138627..2138779	-	153	WP_001153681.1	hypothetical protein	-
AYM26_RS11250	2138769..2142554	-	3786	WP_077467069.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb	2133134..2178133	44999

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T61019 WP_011447039.1 NZ_CP014409:c2137789-2137613 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T61019 NZ_CP014409:c2137789-2137613 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT61019 NZ_CP014409:2137490-2137545 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin