Detailed information of TA system TA060949

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2135767..2136066
• Replicon: chromosome
• Accession: NZ_CP014392
• Organism: Staphylococcus aureus strain USA300-SUR9

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AYM22_RS11230
• Protein ID: WP_011447039.1
• Coordinates: 2135890..2136066 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2135767..2135822 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM22_RS11175	2131098..2131358	+	261	WP_001791826.1	hypothetical protein	-
AYM22_RS11180	2131411..2131761	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AYM22_RS11185	2132446..2132895	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AYM22_RS15795	2132990..2133325	-	336	Protein_2071	SH3 domain-containing protein	-
AYM22_RS11210	2133975..2134466	-	492	WP_000919350.1	staphylokinase	-
AYM22_RS11215	2134657..2135412	-	756	WP_000861038.1	CHAP domain-containing protein	-
AYM22_RS11220	2135424..2135678	-	255	WP_000611512.1	phage holin	-
AYM22_RS11225	2135730..2135837	+	108	WP_001791821.1	hypothetical protein	-
-	2135759..2135898	+	140	NuclAT_0	-	-
-	2135759..2135898	+	140	NuclAT_0	-	-
-	2135759..2135898	+	140	NuclAT_0	-	-
-	2135759..2135898	+	140	NuclAT_0	-	-
-	2135767..2135822	+	56	-	-	Antitoxin
AYM22_RS11230	2135890..2136066	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AYM22_RS11235	2136216..2136512	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AYM22_RS11240	2136570..2136857	-	288	WP_001040261.1	hypothetical protein	-
AYM22_RS11245	2136904..2137056	-	153	WP_001153681.1	hypothetical protein	-
AYM22_RS11250	2137046..2140831	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2131411..2187359	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T60949 WP_011447039.1 NZ_CP014392:c2136066-2135890 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T60949 NZ_CP014392:c2136066-2135890 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT60949 NZ_CP014392:2135767-2135822 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin