Detailed information of TA system TA060928

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1976581..1976763
• Replicon: chromosome
• Accession: NZ_CP014387
• Organism: Staphylococcus aureus strain USA300-SUR8

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: AYM21_RS10180
• Protein ID: WP_001801861.1
• Coordinates: 1976581..1976676 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1976704..1976763 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM21_RS10130	1972241..1972867	+	627	Protein_1912	hypothetical protein	-
AYM21_RS10135	1972908..1973252	+	345	WP_000627551.1	DUF3969 family protein	-
AYM21_RS10140	1973350..1973901	+	552	WP_000414205.1	hypothetical protein	-
AYM21_RS10145	1974119..1974760	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
AYM21_RS10150	1974874..1975059	-	186	WP_000809857.1	hypothetical protein	-
AYM21_RS10155	1975061..1975237	-	177	WP_000375476.1	hypothetical protein	-
AYM21_RS10160	1975248..1975631	-	384	WP_000070811.1	hypothetical protein	-
AYM21_RS10170	1976235..1976378	-	144	WP_001549059.1	transposase	-
AYM21_RS10180	1976581..1976676	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1976704..1976763	-	60	-	-	Antitoxin
AYM21_RS10185	1976799..1976900	+	102	WP_001791893.1	hypothetical protein	-
AYM21_RS10190	1976878..1977054	-	177	Protein_1922	transposase	-
AYM21_RS10195	1977248..1977625	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1946216..2008108	61892

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-116)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T60928 WP_001801861.1 NZ_CP014387:1976581-1976676 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T60928 NZ_CP014387:1976581-1976676 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT60928 NZ_CP014387:c1976763-1976704 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin