Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2602334..2602518 Replicon chromosome
Accession NZ_CP014384
Organism Staphylococcus aureus strain USA300-SUR7

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag AYM20_RS13850 Protein ID WP_000482650.1
Coordinates 2602411..2602518 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2602334..2602394 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM20_RS13825 2597864..2598031 - 168 WP_001790576.1 hypothetical protein -
AYM20_RS13835 2598262..2599995 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
AYM20_RS13840 2600020..2601783 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2602334..2602394 + 61 - - Antitoxin
AYM20_RS13850 2602411..2602518 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
AYM20_RS13855 2602652..2603038 - 387 WP_000779358.1 flippase GtxA -
AYM20_RS13860 2603306..2604448 + 1143 WP_001176863.1 glycerate kinase -
AYM20_RS13865 2604508..2605167 + 660 WP_000831298.1 membrane protein -
AYM20_RS13870 2605349..2606560 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
AYM20_RS13875 2606683..2607156 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T60924 WP_000482650.1 NZ_CP014384:c2602518-2602411 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T60924 NZ_CP014384:c2602518-2602411 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT60924 NZ_CP014384:2602334-2602394 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References