Detailed information of TA system TA060913

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2137439..2137738
• Replicon: chromosome
• Accession: NZ_CP014384
• Organism: Staphylococcus aureus strain USA300-SUR7

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AYM20_RS11235
• Protein ID: WP_011447039.1
• Coordinates: 2137562..2137738 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2137439..2137494 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM20_RS11190	2132770..2133030	+	261	WP_001791826.1	hypothetical protein	-
AYM20_RS11195	2133083..2133433	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AYM20_RS11200	2134118..2134567	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AYM20_RS11205	2134662..2134997	-	336	Protein_2073	SH3 domain-containing protein	-
AYM20_RS11215	2135647..2136138	-	492	WP_000919350.1	staphylokinase	-
AYM20_RS11220	2136329..2137084	-	756	WP_000861038.1	CHAP domain-containing protein	-
AYM20_RS11225	2137096..2137350	-	255	WP_000611512.1	phage holin	-
AYM20_RS11230	2137402..2137509	+	108	WP_001791821.1	hypothetical protein	-
-	2137431..2137570	+	140	NuclAT_0	-	-
-	2137431..2137570	+	140	NuclAT_0	-	-
-	2137431..2137570	+	140	NuclAT_0	-	-
-	2137431..2137570	+	140	NuclAT_0	-	-
-	2137439..2137494	+	56	-	-	Antitoxin
AYM20_RS11235	2137562..2137738	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AYM20_RS11240	2137888..2138184	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AYM20_RS11245	2138242..2138529	-	288	WP_001040261.1	hypothetical protein	-
AYM20_RS11250	2138576..2138728	-	153	WP_001153681.1	hypothetical protein	-
AYM20_RS11255	2138718..2142503	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2133083..2189031	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T60913 WP_011447039.1 NZ_CP014384:c2137738-2137562 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T60913 NZ_CP014384:c2137738-2137562 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT60913 NZ_CP014384:2137439-2137494 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin