Detailed information of TA system TA060867

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2310560..2310823
• Replicon: chromosome
• Accession: NZ_CP014371
• Organism: Staphylococcus aureus strain USA300-SUR4

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: AYM16_RS12265
• Protein ID: WP_001802298.1
• Coordinates: 2310719..2310823 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2310560..2310724 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM16_RS12245	2306743..2307408	-	666	WP_001024094.1	SDR family oxidoreductase	-
AYM16_RS12250	2307560..2307880	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
AYM16_RS12255	2307882..2308862	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
AYM16_RS12260	2309128..2310219	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2310560..2310724	+	165	-	-	Antitoxin
AYM16_RS12265	2310719..2310823	-	105	WP_001802298.1	hypothetical protein	Toxin
AYM16_RS15685	2310984..2311467	-	484	Protein_2270	recombinase family protein	-
AYM16_RS12275	2311510..2312646	-	1137	WP_000115564.1	SAP domain-containing protein	-
AYM16_RS12280	2312935..2313027	+	93	WP_001790138.1	hypothetical protein	-
AYM16_RS12285	2313732..2314589	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
AYM16_RS12290	2314657..2315439	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-99)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T60867 WP_001802298.1 NZ_CP014371:c2310823-2310719 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T60867 NZ_CP014371:c2310823-2310719 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT60867 NZ_CP014371:2310560-2310724 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin