Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2310560..2310823 Replicon chromosome
Accession NZ_CP014371
Organism Staphylococcus aureus strain USA300-SUR4

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag AYM16_RS12265 Protein ID WP_001802298.1
Coordinates 2310719..2310823 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2310560..2310724 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM16_RS12245 2306743..2307408 - 666 WP_001024094.1 SDR family oxidoreductase -
AYM16_RS12250 2307560..2307880 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
AYM16_RS12255 2307882..2308862 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
AYM16_RS12260 2309128..2310219 + 1092 WP_000495671.1 lytic regulatory protein -
- 2310560..2310724 + 165 - - Antitoxin
AYM16_RS12265 2310719..2310823 - 105 WP_001802298.1 hypothetical protein Toxin
AYM16_RS15685 2310984..2311467 - 484 Protein_2270 recombinase family protein -
AYM16_RS12275 2311510..2312646 - 1137 WP_000115564.1 SAP domain-containing protein -
AYM16_RS12280 2312935..2313027 + 93 WP_001790138.1 hypothetical protein -
AYM16_RS12285 2313732..2314589 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
AYM16_RS12290 2314657..2315439 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T60867 WP_001802298.1 NZ_CP014371:c2310823-2310719 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T60867 NZ_CP014371:c2310823-2310719 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT60867 NZ_CP014371:2310560-2310724 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References