Detailed information of TA system TA060841

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2137478..2137777
• Replicon: chromosome
• Accession: NZ_CP014368
• Organism: Staphylococcus aureus strain USA300-SUR3

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AYM15_RS11240
• Protein ID: WP_011447039.1
• Coordinates: 2137601..2137777 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2137478..2137533 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM15_RS11195	2132809..2133069	+	261	WP_001791826.1	hypothetical protein	-
AYM15_RS11200	2133122..2133472	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AYM15_RS11205	2134157..2134606	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AYM15_RS11210	2134701..2135036	-	336	Protein_2073	SH3 domain-containing protein	-
AYM15_RS11220	2135686..2136177	-	492	WP_000919350.1	staphylokinase	-
AYM15_RS11225	2136368..2137123	-	756	WP_000861038.1	CHAP domain-containing protein	-
AYM15_RS11230	2137135..2137389	-	255	WP_000611512.1	phage holin	-
AYM15_RS11235	2137441..2137548	+	108	WP_001791821.1	hypothetical protein	-
-	2137470..2137609	+	140	NuclAT_0	-	-
-	2137470..2137609	+	140	NuclAT_0	-	-
-	2137470..2137609	+	140	NuclAT_0	-	-
-	2137470..2137609	+	140	NuclAT_0	-	-
-	2137478..2137533	+	56	-	-	Antitoxin
AYM15_RS11240	2137601..2137777	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AYM15_RS11245	2137927..2138223	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AYM15_RS11250	2138281..2138568	-	288	WP_001040261.1	hypothetical protein	-
AYM15_RS11255	2138615..2138767	-	153	WP_001153681.1	hypothetical protein	-
AYM15_RS11260	2138757..2142542	-	3786	WP_077467069.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2133122..2189070	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T60841 WP_011447039.1 NZ_CP014368:c2137777-2137601 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T60841 NZ_CP014368:c2137777-2137601 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT60841 NZ_CP014368:2137478-2137533 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin