Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2587621..2587805 Replicon chromosome
Accession NZ_CP014365
Organism Staphylococcus aureus strain USA300-SUR2

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag AYM14_RS13790 Protein ID WP_000482650.1
Coordinates 2587698..2587805 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2587621..2587681 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM14_RS13765 2583151..2583318 - 168 WP_001790576.1 hypothetical protein -
AYM14_RS13775 2583549..2585282 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
AYM14_RS13780 2585307..2587070 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2587621..2587681 + 61 - - Antitoxin
AYM14_RS13790 2587698..2587805 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
AYM14_RS13795 2587939..2588325 - 387 WP_000779358.1 flippase GtxA -
AYM14_RS13800 2588593..2589735 + 1143 WP_001176863.1 glycerate kinase -
AYM14_RS13805 2589795..2590454 + 660 WP_000831298.1 membrane protein -
AYM14_RS13810 2590636..2591847 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
AYM14_RS13815 2591970..2592443 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T60834 WP_000482650.1 NZ_CP014365:c2587805-2587698 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T60834 NZ_CP014365:c2587805-2587698 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT60834 NZ_CP014365:2587621-2587681 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References