Detailed information of TA system TA060822

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1961737..1961919
• Replicon: chromosome
• Accession: NZ_CP014365
• Organism: Staphylococcus aureus strain USA300-SUR2

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: AYM14_RS10105
• Protein ID: WP_001801861.1
• Coordinates: 1961737..1961832 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1961860..1961919 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM14_RS10055	1957397..1958023	+	627	Protein_1898	hypothetical protein	-
AYM14_RS10060	1958064..1958408	+	345	WP_000627551.1	DUF3969 family protein	-
AYM14_RS10065	1958506..1959057	+	552	WP_000414205.1	hypothetical protein	-
AYM14_RS10070	1959275..1959916	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
AYM14_RS10075	1960030..1960215	-	186	WP_000809857.1	hypothetical protein	-
AYM14_RS10080	1960217..1960393	-	177	WP_000375476.1	hypothetical protein	-
AYM14_RS10085	1960404..1960787	-	384	WP_000070811.1	hypothetical protein	-
AYM14_RS10095	1961391..1961534	-	144	WP_001549059.1	transposase	-
AYM14_RS10105	1961737..1961832	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1961860..1961919	-	60	-	-	Antitoxin
AYM14_RS10110	1961955..1962056	+	102	WP_001791893.1	hypothetical protein	-
AYM14_RS10115	1962034..1962210	-	177	Protein_1908	transposase	-
AYM14_RS10120	1962404..1962781	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1931373..1995008	63635

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T60822 WP_001801861.1 NZ_CP014365:1961737-1961832 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T60822 NZ_CP014365:1961737-1961832 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT60822 NZ_CP014365:c1961919-1961860 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin