Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1901525..1901939 Replicon chromosome
Accession NZ_CP014365
Organism Staphylococcus aureus strain USA300-SUR2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AYM14_RS09680 Protein ID WP_076035555.1
Coordinates 1901688..1901939 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AYM14_RS15710 Protein ID WP_000028424.1
Coordinates 1901525..1901698 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM14_RS09640 1897675..1898952 - 1278 WP_000169945.1 PBSX family phage terminase large subunit -
AYM14_RS09645 1898939..1899379 - 441 WP_001003271.1 terminase small subunit -
AYM14_RS09650 1899566..1899985 - 420 WP_000058632.1 transcriptional regulator -
AYM14_RS09655 1900000..1900146 - 147 WP_000990005.1 hypothetical protein -
AYM14_RS09660 1900147..1900320 - 174 WP_031924097.1 transcriptional activator RinB -
AYM14_RS09665 1900317..1900523 - 207 WP_031764620.1 DUF1381 domain-containing protein -
AYM14_RS09670 1900560..1901066 - 507 WP_076035554.1 dUTPase -
AYM14_RS15705 1901081..1901242 - 162 WP_000889682.1 hypothetical protein -
AYM14_RS09675 1901243..1901524 - 282 WP_000454994.1 hypothetical protein -
AYM14_RS15710 1901525..1901698 - 174 WP_000028424.1 hypothetical protein Antitoxin
AYM14_RS09680 1901688..1901939 - 252 WP_076035555.1 DUF1024 family protein Toxin
AYM14_RS09685 1901932..1902321 - 390 WP_033861700.1 hypothetical protein -
AYM14_RS09690 1902318..1902665 - 348 WP_000979209.1 hypothetical protein -
AYM14_RS09695 1902665..1902856 - 192 WP_076035556.1 hypothetical protein -
AYM14_RS09700 1902853..1903233 - 381 WP_076035557.1 hypothetical protein -
AYM14_RS09705 1903247..1903495 - 249 WP_076035558.1 phi PVL orf 51-like protein -
AYM14_RS09710 1903496..1904005 - 510 WP_076035559.1 hypothetical protein -
AYM14_RS09715 1904006..1904191 - 186 WP_072512743.1 DUF3113 family protein -
AYM14_RS09720 1904196..1904600 - 405 WP_076035560.1 DUF1064 domain-containing protein -
AYM14_RS09725 1904611..1904832 - 222 WP_001123685.1 DUF3269 family protein -
AYM14_RS09730 1904835..1905050 - 216 WP_001024406.1 hypothetical protein -
AYM14_RS09735 1905047..1906288 - 1242 WP_001106169.1 AAA family ATPase -
AYM14_RS09740 1906285..1906641 - 357 WP_031764163.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1873494..1917089 43595


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9393.35 Da        Isoelectric Point: 3.8569

>T60820 WP_076035555.1 NZ_CP014365:c1901939-1901688 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQLSVKEGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T60820 NZ_CP014365:c1901939-1901688 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTGATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACTTTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT60820 WP_000028424.1 NZ_CP014365:c1901698-1901525 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT60820 NZ_CP014365:c1901698-1901525 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References