Detailed information of TA system TA060786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3488798..3489360
• Replicon: chromosome
• Accession: NZ_CP014352
• Organism: Acidipropionibacterium acidipropionici strain ATCC 55737

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AXH35_RS15975
• Protein ID: WP_076692624.1
• Coordinates: 3489127..3489360 (-)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: A0A3Q9CPW7
• Locus tag: AXH35_RS15970
• Protein ID: WP_062820485.1
• Coordinates: 3488798..3489103 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXH35_RS15950	3484937..3486229	-	1293	WP_015069928.1	threonine/serine exporter family protein	-
AXH35_RS15955	3486237..3487055	-	819	WP_015069929.1	Nif3-like dinuclear metal center hexameric protein	-
AXH35_RS15960	3487180..3488196	+	1017	WP_062820484.1	YdcF family protein	-
AXH35_RS15970	3488798..3489103	-	306	WP_062820485.1	HigA family addiction module antidote protein	Antitoxin
AXH35_RS15975	3489127..3489360	-	234	WP_076692624.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AXH35_RS15980	3489416..3490837	-	1422	WP_062820486.1	type I glutamate--ammonia ligase	-
AXH35_RS15985	3491050..3492339	+	1290	WP_126132979.1	hypothetical protein	-
AXH35_RS15990	3492363..3492797	+	435	WP_062820488.1	RDD family protein	-
AXH35_RS15995	3492802..3493935	+	1134	WP_062820489.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (19-77)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-72)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8578.58 Da
• Isoelectric Point: 6.6970

>T60786 WP_076692624.1 NZ_CP014352:c3489360-3489127 [Acidipropionibacterium acidipropionici]
IIRPCCQHFTNGSTGGLVRLLNAASELNSPRVPPGNRLEKLVGGRDGQHSIRINDQYRICFVWTDNGADDVEITDYH

Nucleotide

• Length: 234 bp

>T60786 NZ_CP014352:c3489360-3489127 [Acidipropionibacterium acidipropionici]
ATCATCCGCCCGTGCTGCCAGCACTTCACCAACGGCAGCACGGGCGGACTCGTTCGCCTCCTCAACGCGGCCTCAGAACT
GAACAGCCCTCGGGTGCCGCCGGGAAATCGCTTGGAGAAGCTGGTCGGCGGCCGCGACGGCCAGCACTCCATCCGCATCA
ACGACCAGTACCGAATCTGCTTCGTGTGGACCGACAACGGAGCAGACGACGTCGAGATCACCGACTATCACTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11069.56 Da
• Isoelectric Point: 4.6135

>AT60786 WP_062820485.1 NZ_CP014352:c3489103-3488798 [Acidipropionibacterium acidipropionici]
MATASKAHDPITPGEILLTEFLEPMGITQYRLAQATGLSQTRISEIVRGKRAITTDTAPRLSKALGVDDRFWINIQTDYD
LEVEGDLHADELAKVTTLVAS

Nucleotide

• Length: 306 bp

>AT60786 NZ_CP014352:c3489103-3488798 [Acidipropionibacterium acidipropionici]
ATGGCGACAGCATCGAAGGCACACGACCCGATCACTCCCGGCGAGATCCTGCTGACTGAGTTTCTTGAGCCGATGGGCAT
CACGCAGTACCGCCTCGCCCAGGCCACTGGACTCTCCCAGACCCGGATCAGCGAGATCGTGCGCGGCAAGCGCGCCATCA
CCACCGATACCGCCCCCCGGCTGTCCAAGGCCCTCGGGGTCGACGACCGCTTCTGGATCAACATCCAGACCGACTACGAC
CTCGAGGTCGAGGGAGACCTGCACGCCGACGAACTGGCCAAGGTGACCACCCTGGTCGCGAGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q9CPW7