Detailed information of TA system TA060784

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2247693..2248372
• Replicon: chromosome
• Accession: NZ_CP014352
• Organism: Acidipropionibacterium acidipropionici strain ATCC 55737

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: AXH35_RS10300
• Protein ID: WP_099093033.1
• Coordinates: 2247693..2248061 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: -
• Locus tag: AXH35_RS10305
• Protein ID: WP_081685418.1
• Coordinates: 2248061..2248372 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXH35_RS10265	2243538..2243921	+	384	WP_015068789.1	D-ribose pyranase	-
AXH35_RS10270	2243939..2244700	-	762	WP_062819787.1	ABC transporter permease	-
AXH35_RS10275	2244697..2245500	-	804	WP_062819788.1	ATP-binding cassette domain-containing protein	-
AXH35_RS10280	2245497..2245904	-	408	WP_126133026.1	DUF1048 domain-containing protein	-
AXH35_RS10285	2245904..2246221	-	318	WP_198401494.1	PadR family transcriptional regulator	-
AXH35_RS10290	2246383..2247300	-	918	WP_082815990.1	SDR family oxidoreductase	-
AXH35_RS10300	2247693..2248061	+	369	WP_099093033.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AXH35_RS10305	2248061..2248372	+	312	WP_081685418.1	helix-turn-helix domain-containing protein	Antitoxin
AXH35_RS10310	2248535..2248954	-	420	WP_062819791.1	type II toxin-antitoxin system VapC family toxin	-
AXH35_RS10315	2248954..2249217	-	264	WP_015068797.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
AXH35_RS10320	2249339..2249605	-	267	WP_015068798.1	hypothetical protein	-
AXH35_RS10325	2249835..2250284	+	450	WP_062819792.1	CBS domain-containing protein	-
AXH35_RS10330	2250337..2251629	+	1293	WP_062820775.1	ArsB/NhaD family transporter	-
AXH35_RS10335	2251611..2252132	-	522	WP_062819793.1	MFS transporter	-
AXH35_RS10340	2252066..2252923	-	858	WP_062819794.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-113)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13922.00 Da
• Isoelectric Point: 9.4797

>T60784 WP_099093033.1 NZ_CP014352:2247693-2248061 [Acidipropionibacterium acidipropionici]
MVYTCGVWDIDAELIESWVGSLDEASRAQVIAALRILREAGPQLGRPLVDTVKASRYKNIKELRPGSSGRSELRILFAFD
PVRRAILLVAGDKAGDWERWYRKNIPRADDLYEQHLADLKRK

Nucleotide

• Length: 369 bp

>T60784 NZ_CP014352:2247693-2248061 [Acidipropionibacterium acidipropionici]
ATGGTCTATACTTGTGGTGTGTGGGATATCGACGCCGAGCTCATCGAATCCTGGGTGGGTTCCCTGGATGAGGCGTCGCG
GGCTCAGGTGATCGCCGCTCTCCGGATTCTCCGGGAGGCGGGTCCGCAACTCGGCCGCCCTCTCGTCGACACGGTGAAGG
CGTCCCGCTACAAGAACATCAAGGAGTTGCGCCCGGGCTCATCGGGACGATCGGAACTGAGAATCCTGTTCGCCTTCGAT
CCTGTCCGCAGAGCCATCCTCCTGGTAGCCGGCGACAAGGCTGGCGACTGGGAGCGCTGGTACCGCAAGAACATCCCAAG
AGCCGATGACCTGTACGAGCAGCACCTCGCAGACCTGAAACGGAAGTGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11627.24 Da
• Isoelectric Point: 7.0164

>AT60784 WP_081685418.1 NZ_CP014352:2248061-2248372 [Acidipropionibacterium acidipropionici]
MTMSLSLEDLEKRYPVDERLVRAAEDQMRAEVRAYKLRELRERAGLTQAQLAERIGVGQRQVSKIEHGDLDSAKLGTIRR
YLQAVGGDLAVEYVAGDQRLQVA

Nucleotide

• Length: 312 bp

>AT60784 NZ_CP014352:2248061-2248372 [Acidipropionibacterium acidipropionici]
ATGACGATGAGCCTGTCTCTGGAGGATCTGGAGAAGAGGTACCCGGTCGATGAGCGACTCGTCCGGGCCGCCGAGGATCA
GATGCGCGCCGAGGTCCGCGCCTACAAGCTCCGCGAACTGCGTGAGCGCGCCGGGCTCACCCAGGCCCAACTGGCGGAAC
GAATCGGCGTCGGACAGCGGCAGGTCTCCAAGATCGAACATGGCGACCTTGACAGCGCGAAACTCGGCACCATCCGCAGG
TACCTCCAAGCCGTCGGCGGTGACCTCGCCGTTGAGTACGTGGCTGGAGACCAGCGGCTACAAGTCGCCTGA